Search Results
Overview
| Uniprot ID | A0A5S6GB93 |
|---|---|
| Protein Name | Membrane-associated progesterone receptor component 1 |
| Gene Name | PGRMC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 79 | GKVFDVTKGRKFYGP |
| 82 | FDVTKGRKFYGPEGP |
Function
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization
Protein Sequence
10
AAIFTSPLNL
20
LLLGLCIFLL
30
YKIVRGDQPA
40
ASDSDDDEPP
50
PLPRLKRRDF
60
TPAELRRFDG
70
VQDPRILMAI
80
NGKVFDVTKG
90
RKFYGPEGPY
100
GVFAGRDASR
110
GLATFCLDKE
120
ALKDEYDDLS
130
DLTPAQQETL
140
NDWDSQFTFK
150
YHHVGKLLKE
160
GEEPTVYSDE
170
EEPKDESARK
ND
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0030868 | smooth endoplasmic reticulum membrane |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005496 | steroid binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.