Search Results
Overview
| Uniprot ID | A0A5S6GBZ7 |
|---|---|
| Protein Name | Calpain-1 catalytic subunit |
| Gene Name | CAPN1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 140 | ELGPNSSKTYGVKWK |
| 420 | NLTPDALKSQRVRNW |
| 644 | KHKDLRTKGFSLESC |
| 85 | QVQKLRAKELGLGRH |
Function
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7)
Protein Sequence
10
MGSPLSWVLG
20
AQGGGREPDA
30
AGETAVWGGR
40
MAGAAEQHRQ
50
TGAPVLVWGG
60
VGSEQAPLSH
70
RMAEEVITPV
80
YCTGVSAQVQ
90
KLRAKELGLG
100
RHENAIKYLG
110
QDYEQLRAHC
120
LQSGSLFRDE
130
AFPPVPQSLG
140
FKELGPNSSK
150
TYGVKWKRPT
160
ELFSNPQFIV
170
DGATRTDICQ
180
GALGDCWLLA
190
AIASLTLNDT
200
LLHRVVPHGQ
210
SFQNGYAGIF
220
HFQLWQFGEW
230
VDVVVDDLLP
240
TKDGKLVFVH
250
SAQGNEFWSA
260
LLEKAYAKVN
270
GSYEALSGGS
280
TSEGFEDFTG
290
GVTEWYELRK
300
APSDLYSIIL
310
KALERGSLLG
320
CSIDISSVLD
330
MEAVTFKKLV
340
KGHAYSVTGA
350
KQVNYQGQMV
360
NLIRMRNPWG
370
EVEWTGAWSD
380
GSSEWNGVDP
390
YQRDQLRVRM
400
EDGEFWMSFR
410
DFLREFTRLE
420
ICNLTPDALK
430
SQRVRNWNTT
440
LYEGTWRRGS
450
TAGGCRNYPA
460
TFWVNPQFKI
470
RLEETDDPED
480
DYGGRESGCS
490
FVLALMQKHR
500
RRERRFGRDM
510
ETIGFAVYEV
520
PPELVGQPVH
530
LKRDFFLANA
540
SRARSEQFIN
550
LREVSTRFRL
560
PPGEYVVVPS
570
TFEPNKEGDF
580
VLRFFSEKKA
590
GTQELDDQVQ
600
AILPDEQVLS
610
EEEIDENFKA
620
LFRQLAGEDM
630
EISVRELRTI
640
LNRIISKHKD
650
LRTKGFSLES
660
CRSMVNLMDR
670
DGNGKLGLVE
680
FNILWNRIRN
690
YLSIFRKFDL
700
DKSGSMSAYE
710
MRMAIESAGF
720
KLNKKLFELI
730
ITRYSEPDLA
740
VDFDNFVCCL
750
VRLETMFRFF
760
KTLDTDLDGV
770
VTFDLFKWLQ
LTMFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0097264 | self proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.