Overview
| Uniprot ID | A0A5S6GID0 |
|---|
| Protein Name | 26S proteasome regulatory subunit 8 |
|---|
| Gene Name | PSMC5 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 145 |
DKQIKEIKEVIELPV |
| 55 |
QRNELNAKVRLLREE |
| 88 |
DKKKVLVKVHPEGKF |
| 94 |
VKVHPEGKFVVDVDK |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MALDGPEQME
20
LEEGKAGSGL
30
RQYYLSKIEE
40
LQLIVNDKSQ
50
NLRRLQAQRN
60
ELNAKVRLLR
70
EELQLLQEQG
80
SYVGEVVRAM
90
DKKKVLVKVH
100
PEGKFVVDVD
110
KNIDINDVTP
120
NCRVALRNDS
130
YTLEKVPDST
140
YEMIGGLDKQ
150
IKEIKEVIEL
160
PVKHPELFEA
170
LGIAQPKGVL
180
LYGPPGTGKT
190
LLARAVAHHT
200
DCTFIRVSGS
210
ELVQKFIGEG
220
ARMVRELFVM
230
AREHAPSIIF
240
MDEIDSIGSS
250
RLEGGSGGDS
260
EVQRTMLELL
270
NQLDGFEATK
280
NIKVIMATNR
290
IDILDSALLR
300
PGRIDRKIEF
310
PPPNEEARLD
320
ILKIHSRKMN
330
LTRGINLRKI
340
AELMPGASGA
350
EVKGVCTEAG
360
MYALRERRVH
370
VTQEDFEMAV
380
AKVMQKDSEK
NMSIKKLWK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005838 |
proteasome regulatory particle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0140297 |
DNA-binding transcription factor binding |
| Molecular Function |
GO:0140296 |
general transcription initiation factor binding |
| Molecular Function |
GO:0031531 |
thyrotropin-releasing hormone receptor binding |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.