Search Results

Overview

Uniprot ID	A0A5S6GIV5
Protein Name	DNA topoisomerase 2
Gene Name	TOP2A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1011	DHVGCLKKYDTVLDI
1058	QARFILEKIDGKIII
1062	ILEKIDGKIIIENKP
1068	GKIIIENKPKKELIK
1151	LCKLRNEKEQELETL
1276	EPGTKTKKQTTLPFK
1422	TVKKTAAKSQSSTST
265	NGNKLPVKGFRSYVD
397	STCQLSEKFIKAAIG
418	ILNWVKFKAQVQLNK
425	KAQVQLNKKCSAVKH
480	LGVVGRDKYGVFPLR
529	YEDEDSLKTLRYGKI
614	KWKVKYYKGLGTSTS

Function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation

Protein Sequence

10 MEVSPLQPVN 20 ENMQVNKTKK 30 NEEAKKRLSI 40 ERIYQKKTQL 50 EHILLRPDTY 60 IGSVESVTQQ 70 MWVYDEDIGI 80 NYREVTFVPG 90 LYKIFDEILV 100 NAADNKQRDP 110 KMSCIRVTID 120 PENNLISIWN 130 NGKGIPVVEH 140 KVEKMYVPAL 150 IFGQLLTSSN 160 YDDEEKKVTG 170 GRNGYGAKLC 180 NIFSTKFTVE 190 TASREYKKMF 200 KQTWMDNMGR 210 AGEMELKPFN 220 GEDYTCITFH 230 PDLSKFKMQS 240 LDKDIVALMV 250 RRAYDIAGST 260 KDVKVFLNGN 270 KLPVKGFRSY 280 VDLYLKDKVD 290 ETGNPLKIIH 300 EQVNHRWEVC 310 LTMSEKGFQQ 320 ISFVNSIATS 330 KGGRHVDYVA 340 DQIVAKLVDV 350 VKKKNKGGVA 360 VKAHQVKNHM 370 WIFVNALIEN 380 PTFDSQTKEN 390 MTLQVKSFGS 400 TCQLSEKFIK 410 AAIGCGIVES 420 ILNWVKFKAQ 430 VQLNKKCSAV 440 KHNRIKGIPK 450 LDDANDAGGR 460 NSTECTLILT 470 EGDSAKTLAV 480 SGLGVVGRDK 490 YGVFPLRGKI 500 LNVREASHKQ 510 IMENAEINNI 520 IKIVGLQYKK 530 NYEDEDSLKT 540 LRYGKIMIMT 550 DQDQDGSHIK 560 GLLINFIHHN 570 WPSLLRHRFL 580 EEFITPIVKV 590 SKNKQEMAFY 600 SLPEFEEWKS 610 STPNHKKWKV 620 KYYKGLGTST 630 SKEAKEYFAD 640 MKRHRIQFKY 650 SGPEDDAAIS 660 LAFSKKQIDD 670 RKEWLTHFME 680 DRRQRKLLGL 690 PEDYLYGQTT 700 TYLTYNDFIN 710 KELILFSNSD 720 NERSIPSMVD 730 GLKPGQRKVL 740 FTCFKRNDKR 750 EVKVAQLAGS 760 VAEMSSYHHG 770 EMSLMMTIIN 780 LAQNFVGSNN 790 LNLLQPIGQF 800 GTRLHGGKDS 810 ASPRYIFTML 820 SPLARLLFPP 830 KDDHTLKFLY 840 DDNQRVEPEW 850 YIPIIPMVLI 860 NGAEGIGTGW 870 SCKIPNFDVR 880 EVVNNIRLLM 890 DGEEPLPMLP 900 SYKNFKGTIE 910 ELAPNQYVIS 920 GEVAILNSTT 930 IEISELPIRT 940 WTQTYKEQVL 950 EPMLNGTEKT 960 PPLITDYREY 970 HTDTTVKFVV 980 KMTEEKLAEA 990 ERVGLHKVFK 1000 LQTSLTCNSM 1010 VLFDHVGCLK 1020 KYDTVLDILR 1030 DFFELRLKYY 1040 GLRKEWLLGM 1050 LGAESAKLNN 1060 QARFILEKID 1070 GKIIIENKPK 1080 KELIKVLIQR 1090 GYDSDPVKAW 1100 KEAQQKVPDE 1110 EENEESDNEK 1120 EADKSDSVAD 1130 SGPTFNYLLD 1140 MPLWYLTKEK 1150 KDELCKLRNE 1160 KEQELETLKR 1170 KSPSDLWKED 1180 LAAFIEELEA 1190 VEAKEKQDEQ 1200 IGLPGKGGKA 1210 KGKKTQMAEV 1220 LPSPCGKRVI 1230 PRVTVEMKAE 1240 AEKKIKKKIK 1250 SENTEGSPQE 1260 DGMEVEGLKQ 1270 RLEKKQKREP 1280 GTKTKKQTTL 1290 PFKPIKKAKK 1300 RNPWSDSESD 1310 ISSDESNFNV 1320 PPREKEPRRA 1330 AAKTKFTVDL 1340 DSDEDFSDAD 1350 EKTRDEDFVP 1360 SDTSPQKAET 1370 SPKHTNKEPK 1380 PQKSTPSDFD 1390 ADDAKDNVPP 1400 SPSSPVADFP 1410 AVTETIKPVS 1420 KKNVTVKKTA 1430 AKSQSSTSTT 1440 GAKKRAAPKG 1450 AKKDPDLDSD 1460 VSKKPNPPKP 1470 KGRRKRKPST 1480 SDDSDSNFEK 1490 MISKAVTSKK 1500 PKGESDDFHL 1510 DLDLAVASRA 1520 KSGRTKKPIK 1530 YLEESDEDDL F

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005814	centriole
Cellular Component	GO:0000775	chromosome, centromeric region
Cellular Component	GO:0000793	condensed chromosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Component	GO:0000228	nuclear chromosome
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0008301	DNA binding, bending
Molecular Function	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0005080	protein kinase C binding
Molecular Function	GO:0043130	ubiquitin binding
Biological Process	GO:0030263	apoptotic chromosome condensation
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0007059	chromosome segregation
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006265	DNA topological change
Biological Process	GO:0007143	female meiotic nuclear division
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
Biological Process	GO:0042752	regulation of circadian rhythm
Biological Process	GO:0048511	rhythmic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.