Overview
| Uniprot ID | A0A5S6GNK8 |
|---|
| Protein Name | ATP synthase F(0) complex subunit e, mitochondrial |
|---|
| Gene Name | ATP5ME |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 194 |
AKRYNYLKPRAEEER |
Function
Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain
Protein Sequence
10
MTPSPSPGSQ
20
RALMPGAAQG
30
PGDGWSSHQS
40
LSPIAMATMP
50
LSAQEAQLGG
60
SVATTASLWG
70
APLHTWTGQA
80
VSSLGGCRAR
90
GDSFEGAECP
100
TSATSASLAE
110
GSRSARAVPP
120
LDTRGQGTVP
130
ACCRRRMRFP
140
ECASTSPRFS
150
GLLRRPPRSD
160
SASGAKVTDK
170
MVPPVQVSPL
180
IKLGRYSALF
190
LGVAYGAKRY
200
NYLKPRAEEE
210
RRIAAEEKKK
220
QDELKRIERE
230
LAEAQEDSIL
K
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0046933 |
proton-transporting ATP synthase activity, rotational mechanism |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.