Search Results
Overview
| Uniprot ID | A0A5S6GR81 |
|---|---|
| Protein Name | Cathepsin B |
| Gene Name | CTSB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | VDLSYVKKLCGTFLG |
| 148 | GTFLGGPKLPQRAAF |
| 178 | WPNCPTIKEIRDQGS |
| 304 | TPSYKEDKHFGCSSY |
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis
Protein Sequence
10
MRPDSSWMLR
20
LVKALPTPRL
30
QKRKQEHRGQ
40
VAGPGWEQGP
50
FDHCCSWPQN
60
SCLRWIKPMN
70
QRILMSCILD
80
FLGESRIHLP
90
KMWRLLATLS
100
CLVLLTSARE
110
SLHFQPLSDE
120
LVNFINKQNT
130
TWTAGHNFYN
140
VDLSYVKKLC
150
GTFLGGPKLP
160
QRAAFAADMI
170
LPKSFDAREQ
180
WPNCPTIKEI
190
RDQGSCGSCW
200
AFGAVEAISD
210
RICIRSNGRV
220
NVEVSAEDML
230
TCCGDECGDG
240
CNGGFPSGAW
250
NFWTKKGLVS
260
GGLYDSHVGC
270
RPYSIPPCEH
280
HVNGSRPPCT
290
GEGDTPKCSK
300
ICEPGYTPSY
310
KEDKHFGCSS
320
YSISRNEKEI
330
MAEIYKNGPV
340
EGAFTVYSDF
350
LQYKSGVYQH
360
VTGDLMGGHA
370
IRILGWGVEN
380
GTPYWLVGNS
390
WNTDWGDNGF
400
FKILRGQDHC
410
GIESEIVAGI
PCTPHF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0043394 | proteoglycan binding |
| Biological Process | GO:0097067 | cellular response to thyroid hormone stimulus |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
| Biological Process | GO:0046718 | symbiont entry into host cell |
| Biological Process | GO:0006590 | thyroid hormone generation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.