Search Results
Overview
| Uniprot ID | A0A5S6GXI4 |
|---|---|
| Protein Name | Transferrin receptor protein 1 |
| Gene Name | TFRC |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | DLKILLSKGLDTTDF |
| 295 | LVIVRAGKITFAEKV |
| 398 | WRTDFPCKLVSSPSK |
| 405 | KLVSSPSKNVKLTVN |
| 408 | SSPSKNVKLTVNNVL |
| 565 | RDSNWINKVEKLSFD |
Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway
Protein Sequence
10
MAFGVCVDDL
20
ELLALGFLGS
30
FVWQLRMMDQ
40
ARSAFSSLFG
50
GEPLSYTRFS
60
LARQVDGDNS
70
HVEMKLAADE
80
EENVDSNTRS
90
NHIGVAKPKR
100
LNGYVCYGII
110
AVITFFLIGF
120
MIGYLAYCKR
130
VESKTDCKTL
140
VPTEPSETEE
150
TETFEAENFP
160
QTPRLFWADL
170
KILLSKGLDT
180
TDFTRTIKML
190
NEDYAPREAG
200
SQKDESLGFF
210
IENQFREFKL
220
SKVWHDEHFV
230
KIQVKGSNAE
240
NSVTLVNTDS
250
NSLVYPVESP
260
EGYVAYSKAT
270
TVTGKLIFAN
280
FGTKKDFEDL
290
KMPVNGSLVI
300
VRAGKITFAE
310
KVANAQSLDA
320
IGVLIYMDRA
330
NFPIINADVP
340
VFGHAHLGTG
350
DPYTPGFPSF
360
NHTQFPPSQS
370
SGLPNIPVQT
380
ISRAGAEKLF
390
GNMEQDCPLT
400
WRTDFPCKLV
410
SSPSKNVKLT
420
VNNVLKEIKI
430
LNIFGVIKGF
440
EEPDRYVIVG
450
AQRDAWGPGA
460
AKSSVGTSLL
470
LNLAQILSDM
480
VIKGQFKPSR
490
SIVFASWSAG
500
DFGAIGATEW
510
LEGYLSSLHL
520
KAFTYINLDK
530
AVLGTSNFKV
540
SASPLLYSLI
550
EKMMQDVKNP
560
VTGQSLYRDS
570
NWINKVEKLS
580
FDDAAFPFLA
590
YSGIPAVSFC
600
FCEDTDYPYL
610
GTTMDTYDVL
620
SKRVPQLNRM
630
ARAAAEVAGH
640
LVIKLTIDFE
650
LNLNYEMYND
660
KILSFVREMN
670
QFRVDIREMG
680
LSLQWLYSAR
690
GDFFRATSRL
700
TSDYRNVETR
710
DKFVMREIND
720
RIMKVEYHFL
730
SPYVSPRESP
740
FRHIFWGSGS
750
HTLSALVEHL
760
KLRQKNSSAF
770
NQTLLKNQLA
780
LATWTIQGAA
790
NALSGDIWDI
DNEF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:1990712 | HFE-transferrin receptor complex |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0055037 | recycling endosome |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0004998 | transferrin receptor activity |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0006826 | iron ion transport |
| Biological Process | GO:0060586 | multicellular organismal-level iron ion homeostasis |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010637 | negative regulation of mitochondrial fusion |
| Biological Process | GO:0030316 | osteoclast differentiation |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0045830 | positive regulation of isotype switching |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| Biological Process | GO:0033572 | transferrin transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.