Search Results
Overview
| Uniprot ID | A0A5S6HDE4 |
|---|---|
| Protein Name | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial |
| Gene Name | HADH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | DFSKTLGKHPVSCKD |
| 202 | GKHPVSCKDTPGFIV |
| 291 | NKLVAENKFGKKTGE |
| 302 | KTGEGFYKYK***** |
| 87 | KKFAENPKAGDEFVE |
Function
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes
Protein Sequence
10
MAFATRQLVR
20
SLSSSSTAAA
30
SAKKILVKHV
40
TVIGGGLMGA
50
GIAQVAAATG
60
HTVVLVDQTE
70
DILAKSKKGI
80
EESLRKVAKK
90
KFAENPKAGD
100
EFVEKTLSSI
110
STSTDAASVV
120
HSTDLVVEAI
130
VENLKVKSEL
140
FKRLDKFAAE
150
YVTPGDLVGL
160
RLSSAAWAPL
170
QGRKFFSALH
180
FQVVKTPMTS
190
QKTLESLVDF
200
SKTLGKHPVS
210
CKDTPGFIVN
220
RLLVPYLIEA
230
VRLYERGDAS
240
KEDIDTAMKL
250
GAGYPMGPFE
260
LLDYVGLDTT
270
KFIIDGWHEM
280
DSQNPLFQPS
290
PAMNKLVAEN
300
KFGKKTGEGF
YKYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0003857 | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| Molecular Function | GO:0070403 | NAD+ binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.