Search Results

Overview

Uniprot ID	A0A5S6HMR6
Protein Name	Prolyl endopeptidase
Gene Name	PREP
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
516	EYGETWHKGGILANK

Function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long

Protein Sequence

10 MLSFQYPDVY 20 RDETAIQDYH 30 GHKVCDPYAW 40 LEDPDSEQTK 50 AFVEAQNKIT 60 VPFLEQCPIR 70 GLYKERMTEL 80 YDYPKYSCHF 90 KKGKRYFYFY 100 NTGLQNQRVL 110 YVQDSLEGEA 120 RVFLDPNILS 130 DDGTVALRGY 140 AFSEDGEYFA 150 YGLSASGSDW 160 VTIKFMKVDG 170 AKELPDVLER 180 VKFSCMAWTH 190 DGKGMFYNAY 200 PQQDGKSDGT 210 ETSTNLHQKL 220 YYHVLGTDQS 230 EDILCAEFPD 240 EPKWMGGAEL 250 SDDGRYVLLS 260 IREGCDPVNR 270 LWYCDLQQES 280 NGITGILKWV 290 KLIDNFEGEY 300 DYVTNEGTVF 310 TFKTNRHSPN 320 YRLINIDFTD 330 PEESKWKVLV 340 PEHEKDVLEW 350 VACVRSNFLV 360 LCYLHDVKNT 370 LQLHDLATGA 380 LLKIFPLEVG 390 SVVGYSGQKK 400 DTEIFYQFTS 410 FLSPGIIYHC 420 DLTKEELEPR 430 VFREVTVKGI 440 DASDYQTVQI 450 FYPSKDGTKI 460 PMFIVHKKGI 470 KLDGSHPAFL 480 YGYGGFNISI 490 TPNYSVSRLI 500 FVRHMGGVLA 510 VANIRGGGEY 520 GETWHKGGIL 530 ANKQNCFDDF 540 QCAAEYLIKE 550 GYTSPKRLTI 560 NGGSNGGLLV 570 ATCANQRPDL 580 FGCVIAQVGV 590 MDMLKFHKYT 600 IGHAWTTDYG 610 CSDSKQHFEW 620 LIKYSPLHNV 630 KLPEADDIQY 640 PSMLLLTADH 650 DDRVVPLHSL 660 KFIATLQYIV 670 GRSRKQNNPL 680 LIHVDTKAGH 690 GAGTPPAAEN 700 LKGCPAIKTE 710 KPLDVTLPHT 720 NTQPALRLQL 730 NRTASGILSF 740 LGFSFLTGPW 750 RFFSALCRHM F

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0004181	metallocarboxypeptidase activity
Molecular Function	GO:0004252	serine-type endopeptidase activity
Biological Process	GO:0002003	angiotensin maturation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.