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Overview

Uniprot IDA0A5S6HSJ6
Protein NameCalcium-transporting ATPase
Gene NameATP2A2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
163 DIRLTSIKSTTLRVD
475 VIKQLMKKEFTLEFS
537 MTPGVKQKIMSVIRE
605 IEVASSVKLCRQAGI
989 RNYLEPGKECVQPAT

Function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium

Protein Sequence

10 MENAHTKTVE 20 EVLGHFGVNE 30 STGLSLEQVK 40 KLKERWGSNG 50 KTLLELVIEQ 60 FEDLLVRILL 70 LAACISFVLA 80 WFEEGEETIT 90 AFVEPFVILL 100 ILVANAIVGV 110 WQERNAENAI 120 EALKEYEPEM 130 GKVYRQDRKS 140 VQRIKAKDIV 150 PGDIVEIAVG 160 DKVPADIRLT 170 SIKSTTLRVD 180 QSILTGESVS 190 VIKHTDPVPD 200 PRAVNQDKKN 210 MLFSGTNIAA 220 GKAMGVVVAT 230 GVNTEIGKIR 240 DEMVATEQER 250 TPLQQKLDEF 260 GEQLSKVISL 270 ICIAVWIINI 280 GHFNDPVHGG 290 SWIRGAIYYF 300 KIAVALAVAA 310 IPEGLPAVIT 320 TCLALGTRRM 330 AKKNAIVRSL 340 PSVETLGCTS 350 VICSDKTGTL 360 TTNQMSVCRM 370 FILDKVEGDT 380 CSLNEFTITG 390 STYAPIGEVH 400 KDDKPVKCHQ 410 YDGLVELATI 420 CALCNDSALD 430 YNEAKGVYEK 440 VGEATETALT 450 CLVEKMNVFD 460 TELKGLSKIE 470 RANACNSVIK 480 QLMKKEFTLE 490 FSRDRKSMSV 500 YCTPNKPSRT 510 SMSKMFVKGA 520 PEGVIDRCTH 530 IRVGSTKVPM 540 TPGVKQKIMS 550 VIREWGSGSD 560 TLRCLALATH 570 DNPMRREEMN 580 LEDSANFIKY 590 ETNLTFVGCV 600 GMLDPPRIEV 610 ASSVKLCRQA 620 GIRVIMITGD 630 NKGTAVAICR 640 RIGIFGQDED 650 VTSKAFTGRE 660 FDELNPSAQR 670 EACLNARCFA 680 RVEPSHKSKI 690 VEFLQSFDEI 700 TAMTGDGVND 710 APALKKSEIG 720 IAMGSGTAVA 730 KTASEMVLAD 740 DNFSTIVAAV 750 EEGRAIYNNM 760 KQFIRYLISS 770 NVGEVVCIFL 780 TAALGFPEAL 790 IPVQLLWVNL 800 VTDGLPATAL 810 GFNPPDLDIM 820 NKPPRNPKEP 830 LISGWLFFRY 840 LAIGCYVGAA 850 TVGAAAWWFI 860 AADGGPRVTF 870 YQLSHFLQCK 880 EDNPDFEGVD 890 CAVFESPYPM 900 TMALSVLVTI 910 EMCNALNSLS 920 ENQSLLRMPP 930 WENIWLVGSI 940 CLSMSLHFLI 950 LYVEPLPLIF 960 QITPLNLTQW 970 LMVLKISLPV 980 ILMDETLKFV 990 ARNYLEPGKE 1000 CVQPATKSCS 1010 FSWGKIFLFY THN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005388 P-type calcium transporter activity
Biological Process GO:1990036 calcium ion import into sarcoplasmic reticulum
Biological Process GO:0003012 muscle system process
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0006937 regulation of muscle contraction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.