Search Results
Overview
| Uniprot ID | A0A5S6I1M3 |
|---|---|
| Protein Name | Alpha-crystallin B chain |
| Gene Name | CRYAB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 149 | SPEELKVKVLGDVIE |
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome
Protein Sequence
10
MRRRLRSEVR
20
PQQSQRDPSS
30
CRRRARKLHK
40
TAYIRGWLEL
50
QLKELTGQLT
60
LYIHPAAMDI
70
AIHHPWIRRP
80
FFPFHSPSRL
90
FDQFFGEHLL
100
ESDLFPASTS
110
LSPFYFRPPS
120
FLRAPSWIDT
130
GLSEMRLEKD
140
RFSVNLDVKH
150
FSPEELKVKV
160
LGDVIEVHGK
170
HEERQDEHGF
180
ISREFHRKYR
190
IPADVDPLTI
200
TSSLSSDGVL
210
TVNGPRRQAS
220
GPERTIPITR
230
EEKPAVTAAP
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0009892 | negative regulation of metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.