Overview
| Uniprot ID | A0A5S6IBF3 |
|---|
| Protein Name | ADP-ribosylation factor-like protein 3 |
|---|
| Gene Name | ARL3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 27 |
LSILRKLKSAPDQEV |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium
Protein Sequence
10
YQIQCPQSNL
20
SSSWLFKGLL
30
SILRKLKSAP
40
DQEVRILLLG
50
LDNAGKTTLL
60
KQLASEDISH
70
ITPTQGFNIK
80
SVQSQGFKLN
90
VWDIGGQRKI
100
RPYWRNYFEN
110
TDILIYVIDS
120
ADRKRFEETG
130
QELAELLEEE
140
KLSCVPVLIF
150
ANKQDLLTAA
160
PASEIAEGLN
170
LHTIRDRVWQ
180
IQSCSALTGE
190
GVQDGMNWVC
KNVNAKKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.