Search Results

Overview

Uniprot ID	A0A5S6ICQ1
Protein Name	Neurolysin, mitochondrial
Gene Name	NLN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
244	HYFPVMKKCCIPETR
331	REFILNLKKKECEEK

Function

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 YSALVGGSGI 20 LLRMTLGREA 30 MSPLQAMSSY 40 TVDGRNVLRW 50 DLSPEQIKRR 60 TEELIAQTKQ 70 VYDDIGMLDI 80 EEVTYENCLQ 90 ALADVEVKYI 100 VERTMLDFPQ 110 HVSSDKEVRA 120 ASTEADKRLS 130 RFDIEMSMRE 140 DIFLRIVRLK 150 ETCDLGKIKP 160 EARRYLEKSV 170 KMGKRNGLHL 180 PEQVQNEIKA 190 MKKRMSELCI 200 DFNKNLNEDD 210 TFLVFSKAEL 220 GALPDDFIDS 230 LEKTDDNKYK 240 ITLKYPHYFP 250 VMKKCCIPET 260 RRKMEMAFNT 270 RCKEENTIIL 280 QELLPLRAKV 290 AKLLGYSTHA 300 DFVLEMNTAK 310 STHHVTAFLD 320 DLSQKLKPLG 330 EAEREFILNL 340 KKKECEEKGF 350 EYDGKINAWD 360 LHYYMTQTEE 370 LKYSVDQEIL 380 KEYFPIEVVT 390 EGLLNIYQEL 400 LGLSFEQVTD 410 AHVWNKSVTL 420 YTVKDKATGE 430 VLGQFYLDLY 440 PREGKYNHAA 450 CFGLQPGCLL 460 PDGSRMMSVA 470 ALVVNFSQPR 480 AGRPSLLRHD 490 EVRTYFHEFG 500 HVMHQICAQT 510 DFARFSGTNV 520 ETDFVEVPSQ 530 MLENWVWDTD 540 SLRRLSKHYK 550 DGSPITDDLL 560 EKLVASRLVN 570 TGLLTLRQIV 580 LSKVDQSLHT 590 NTSLDAASEY 600 AKYCTEILGV 610 AATPGTNMPA 620 TFGHLAGGYD 630 GQYYGYLWSE 640 VFSMDMFYSC 650 FKKEGIMNPE CVFHSV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.