Search Results
Overview
| Uniprot ID | A0A5S6IIV1 |
|---|---|
| Protein Name | Ribonuclease inhibitor |
| Gene Name | RNH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 169 | LRATRALKELTVSNN |
| 213 | GLTPANCKDLCGIVA |
| 279 | LCRVLQAKETLKELS |
| 283 | LQAKETLKELSLAGN |
| 291 | ELSLAGNKLGDEGAR |
| 42 | GLTEEHCKDIGSALR |
| 450 | LQALEGSKPGLRVIS |
| 85 | SPTCKIQKLSLQNCS |
Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus
Protein Sequence
10
GMNLDIHCEQ
20
LSDARWTELL
30
PLLQQYEVVR
40
LDDCGLTEEH
50
CKDIGSALRA
60
NPSLTELCLR
70
TNELGDAGVH
80
LVLQGLQSPT
90
CKIQKLSLQN
100
CSLTEAGCGV
110
LPSTLRSLPT
120
LRELHLSDNP
130
LGDAGLRLLC
140
EGLLDPQCHL
150
EKLQLEYCRL
160
TAASCEPLAS
170
VLRATRALKE
180
LTVSNNDIGE
190
AGARVLGQGL
200
ADSACQLETL
210
RLENCGLTPA
220
NCKDLCGIVA
230
SQASLRELDL
240
GSNGLGDAGI
250
AELCPGLLSP
260
ASRLKTLWLW
270
ECDITASGCR
280
DLCRVLQAKE
290
TLKELSLAGN
300
KLGDEGARLL
310
CESLLQPGCQ
320
LESLWVKSCS
330
LTAACCQHVS
340
LMLTQNKHLL
350
ELQLSSNKLG
360
DSGIQELCQA
370
LSQPGTTLRV
380
LCLGDCEVTN
390
SGCSSLASLL
400
LANRSLRELD
410
LSNNCVGDPG
420
VLQLLGSLEQ
430
PGCALEQLVL
440
YDTYWTEEVE
450
DRLQALEGSK
PGLRVIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032311 | angiogenin-PRI complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0008428 | ribonuclease inhibitor activity |
| Biological Process | GO:0045765 | regulation of angiogenesis |
| Biological Process | GO:0036416 | tRNA stabilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.