Search Results
Overview
| Uniprot ID | A0A5S8KLN1 |
|---|---|
| Protein Name | Clusterin |
| Gene Name | CLU |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 286 | SNDRAVCKEIRHNST |
Function
Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins
Protein Sequence
10
EMKTLLLLVG
20
LLLTWENGPW
30
VLGDKAISDK
40
ELQEMSTEGS
50
KYVNKEIKNA
60
LKEVKQIKTL
70
IEQSNEERKS
80
LLSSLEEAKK
90
KKEDALNDTR
100
DTETKLKGSQ
110
GLCNETMMAL
120
WEECKPCLKQ
130
TCMKFYARVC
140
RSGSGLVGHQ
150
LEEFLNQSSP
160
FYFWINGDRI
170
DSLMENDRQQ
180
SHVMDIMEDS
190
FNRASNIMDE
200
LFQDRFFNRE
210
PFDTQFFSPF
220
GSSHRGSLFF
230
NPKSRFARNI
240
MPFPLFTDLN
250
YHDMFQPFFD
260
MIHQAQQAMD
270
AHLHRIPYHF
280
PEAGVPENSN
290
DRAVCKEIRH
300
NSTGCLRMKD
310
QCEKCREILS
320
VDCSASNSSQ
330
MQLRQELYTS
340
LQMAEKFSKL
350
YDQLLQSYQQ
360
KMLNTSSLLK
370
QLNEQFSWVS
380
QLANLTQNDD
390
RYYLQVTTVN
400
SHGSDPSVPS
410
GLTKVVVKLF
420
DSYPITLIIP
430
QEVSDPKFME
440
TVAEEALQQY
RQRSREE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097440 | apical dendrite |
| Biological Process | GO:0001774 | microglial cell activation |
| Biological Process | GO:0061518 | microglial cell proliferation |
| Biological Process | GO:0001971 | negative regulation of activation of membrane attack complex |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:1902430 | negative regulation of amyloid-beta formation |
| Biological Process | GO:1903660 | negative regulation of complement-dependent cytotoxicity |
| Biological Process | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:1903573 | negative regulation of response to endoplasmic reticulum stress |
| Biological Process | GO:1902004 | positive regulation of amyloid-beta formation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:1902998 | positive regulation of neurofibrillary tangle assembly |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0017038 | protein import |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0061740 | protein targeting to lysosome involved in chaperone-mediated autophagy |
| Biological Process | GO:1900221 | regulation of amyloid-beta clearance |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:1902847 | regulation of neuronal signal transduction |
| Biological Process | GO:0051788 | response to misfolded protein |
| Biological Process | GO:0009615 | response to virus |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0042583 | chromaffin granule |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0097418 | neurofibrillary tangle |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0099020 | perinuclear endoplasmic reticulum lumen |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0034366 | spherical high-density lipoprotein particle |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0051787 | misfolded protein binding |
| Molecular Function | GO:0140597 | protein carrier chaperone |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0097242 | amyloid-beta clearance |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0032286 | central nervous system myelin maintenance |
| Biological Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Biological Process | GO:0002434 | immune complex clearance |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.