Search Results
Overview
| Uniprot ID | A0A5S8KXS2 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha |
| Gene Name | CAPZA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | NGKFLDPKNRICFKF |
| 109 | PKNRICFKFDHLRKE |
| 115 | FKFDHLRKEATDPRP |
| 145 | TALRAYVKEHYPNGV |
| 158 | GVCTVYGKKIDGQQT |
| 159 | VCTVYGKKIDGQQTI |
| 280 | QLPVTRTKIDWNKIL |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments
Protein Sequence
10
MADLEEQLSD
20
EEKVRIAAKF
30
IIHAPPGEFN
40
EVFNDVRLLL
50
NNDNLLREGA
60
AHAFAQYNLD
70
QFTPVKIEGY
80
EDQVWEKEKL
90
DRRLKVLITE
100
HGDLGNGKFL
110
DPKNRICFKF
120
DHLRKEATDP
130
RPYEAENAVE
140
SWRTSVETAL
150
RAYVKEHYPN
160
GVCTVYGKKI
170
DGQQTIIACI
180
ESHQFQAKNF
190
WNGRWRSEWK
200
FTITPSTTQV
210
VGILKIQVHY
220
YEDGNVQLVS
230
HKDIQDSLTV
240
SNEVQTAKEF
250
IKIVEAAENE
260
YQTAISENYQ
270
TMSDTTFKAL
280
RRQLPVTRTK
290
IDWNKILSYK
IGKEMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.