Search Results
Overview
| Uniprot ID | A0A6I8PU73 |
|---|---|
| Protein Name | DnaJ homolog subfamily C member 7 |
| Gene Name | DNAJC7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | LLDDQEAKREAETFK |
Function
Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm
Protein Sequence
10
MAAAAECDVV
20
MAATEPELLD
30
DQEAKREAET
40
FKEQGNAYYA
50
KKDYNEAYNY
60
YTKAIDMCPK
70
NASYYGNRAA
80
TLMMLGRFRE
90
ALGDAQQSVR
100
LDDSFVRGHL
110
REGKCHLSLG
120
NAMAACRSFQ
130
RALELDHKNA
140
QAQQEFKNAN
150
AVMEYEKIAE
160
TDFEKRDFRK
170
VVFCMDRALE
180
FAPACHRFKI
190
LKAECLAMLG
200
RYPEAQSVAS
210
DILRMDSTNA
220
DALYVRGLCL
230
YYEDCIEKAV
240
QFFVQALRMA
250
PDHEKACIAC
260
RNAKALKAKK
270
EDGNKAFKEG
280
NYKLAYELYT
290
EALGIDPNNI
300
KTNAKLYCNR
310
GTVNSKLRKL
320
DDAIEDCTNA
330
VKLDDTYIKA
340
YLRRAQCYMD
350
TEQYEEAVRD
360
YEKVYQTEKT
370
KEHKQLLKNA
380
QLELKKSKRK
390
DYYKILGVDK
400
NASEDEIKKA
410
YRKRALMHHP
420
GRVDRHSGAS
430
AEVQKEEEKK
440
FKEVGEAFTI
450
LSDPKKKTRY
460
DSGQDLDEEG
470
MNMGDFDPNN
480
IFKAFFGGPG
490
GFSFEASGPG
NFFFQFG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
Reference
PMID: N/A