Search Results
Overview
| Uniprot ID | A0A6J1RY87 |
|---|---|
| Protein Name | thioredoxin-disulfide reductase (NADPH) |
| Gene Name | LOC113201828 |
| Organism | Frankliniella occidentalis |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 94 | GWNIPERKSISLDWA |
Function
Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms
Protein Sequence
10
MAPVQAGSHG
20
FDYDLVVIGG
30
GSGGLAAAKE
40
AVSLGKKVAV
50
LDFVDPSPRG
60
TTWGLGGTCV
70
NVGCIPKKLF
80
HQAALLGESL
90
HDAGCFGWNI
100
PERKSISLDW
110
AKLRESVQNH
120
IKSVNWVLRV
130
ELRDKKVEYI
140
NARGSLIDTH
150
TVHAKLKNGS
160
ERELKTEHVL
170
LAMGGRPIYP
180
DIPGAVENCI
190
TSDDIFSLPE
200
APGKTLVIGA
210
GYIGLECAGF
220
LNEFGMDATV
230
MVRSTVLRGF
240
DQQMAGLISE
250
EMKSRGVKFL
260
HKTVPVRMDK
270
QADGKIKVTW
280
KSLENNSESS
290
DLFDTVLMAT
300
GRRPLTLEVK
310
ADQVGVKLHP
320
ESKKVVSEKE
330
LTNIPNIFAV
340
GDILEGKPEL
350
TPVAIQAGKL
360
LAQRLYNNGK
370
IEMDYDNVAT
380
TVFTPLEYGC
390
CGLSEEEAIR
400
RHGDDNIEVY
410
HAFYKPTEFF
420
VPQRSPARCY
430
MKVVCLRAAP
440
QKVLGMHYTG
450
PQGGEVIQGY
460
AAAIKMGLTM
470
EVLMDTVGIH
480
PTVSEEFTRL
490
WITKRSGIDP
TPQSCCS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0004362 | glutathione-disulfide reductase (NADPH) activity |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0006749 | glutathione metabolic process |
Reference
[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.