Overview
| Uniprot ID | A0A6J1RZZ9 |
|---|
| Protein Name | Cytochrome c oxidase subunit 5A, mitochondrial |
|---|
| Gene Name | LOC113202228 |
|---|
| Organism | Frankliniella occidentalis |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 86 |
KIIVAALKACRRLND |
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Protein Sequence
10
MLRSVAMRVH
20
GAVRSGVLQT
30
AVRSPAAIQQ
40
RLSHGKPELS
50
EEEFDQKYVD
60
FFSRPNIDGW
70
EIRTAMNDLA
80
RMDLIPEPKI
90
IVAALKACRR
100
LNDYAVAVRF
110
LESVKDKCGT
120
KANEIYPWII
130
QEIRPTLDEL
140
GISTPEELGY
150
DKPELAIQDV
EDMH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045277 |
respiratory chain complex IV |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
Reference
[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.