Search Results

Overview

Uniprot IDA0A6J1SCT2
Protein NameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Gene NameLOC113205147
OrganismFrankliniella occidentalis

Kla Sites from experimental identification

Position Flanking peptide
124 DISEKMLKQTLVTKQ
130 LKQTLVTKQTGEKGK
137 KQTGEKGKICNAVMV
212 VALKVADKVGLKDQR
235 KLYDLFLKKDALLVE
348 NQVKEAFKIITSDPK
76 EAVDIANKLGTKDLV
80 IANKLGTKDLVVKAQ
99 GRGKGSFKNGFKGGV

Function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit

Protein Sequence

10 MATILKSGIL 20 PLEAIIRRNG 30 GKLLGATTSL 40 PNLRQPKRNL 50 NLHEHMSYTF 60 LNEAGIETPK 70 FGVATTKSEA 80 VDIANKLGTK 90 DLVVKAQVLA 100 GGRGKGSFKN 110 GFKGGVRMAF 120 SPEEVGDISE 130 KMLKQTLVTK 140 QTGEKGKICN 150 AVMVAERSYP 160 RKEYYFSIMM 170 ERAFNGPVVI 180 ASSQGGVNIE 190 DVAAENPDAI 200 LYEPIDVIQG 210 LTREVALKVA 220 DKVGLKDQRD 230 NTADMLLKLY 240 DLFLKKDALL 250 VELNPYAENA 260 DGRYLTLDAK 270 MNFDDNADFR 280 QKELFAKRDL 290 TQQDEKEVEA 300 LKYNLNYIAL 310 DGSIGCLVNG 320 AGLAMATMDI 330 IKLHGGNPAN 340 FLDVGGGATA 350 NQVKEAFKII 360 TSDPKVHTIL 370 VNIFGGIMRC 380 DVIAEGIIAA 390 CKELNLNVPI 400 VCRLQGTEVD 410 TAKVLIASAG 420 LKILPTDDLD 430 EAARLAVKLS 440 NIVGMARSAN LNINFEIPI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0042709 succinate-CoA ligase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004775 succinate-CoA ligase (ADP-forming) activity
Molecular Function GO:0004776 succinate-CoA ligase (GDP-forming) activity
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.