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Overview

Uniprot ID	A0A6J1SHL1
Protein Name	Glycine--tRNA ligase
Gene Name	LOC113208071
Organism	Frankliniella occidentalis

Kla Sites from experimental identification

Position	Flanking peptide
235	LEKLASEKTATSELK

Function

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Required for terminal arborization of both dendrites and axons during development

Protein Sequence

10 MKILSPLSRI 20 AFIGLACKER 30 HFPQLVRSIA 40 VSSAASRKGE 50 RQLWGTTKKT 60 RTLRLLPWEI 70 MADPKIEEAL 80 APLRAAVKEQ 90 GDLVRSLKQS 100 GAPDLDVKKA 110 VVELKARKKI 120 LEDKELSLIP 130 NVATFDRAKM 140 EDLLKRRFFF 150 DQSFAIYGGI 160 TGQFDFGPMG 170 CAMKANMLNT 180 WRSFFVLEEQ 190 MLEVDCSILT 200 PEPVLKASGH 210 VDRFADLMVK 220 DVKNGNCFRL 230 DHLIKAHLEK 240 LASEKTATSE 250 LKAECTDIVV 260 KLDGMTKDEM 270 ANILKKFNIK 280 APLTNNDLTE 290 PIEFNLMFAT 300 QIGPSGLVKG 310 FLRPETAQGI 320 FVNFKRLLEF 330 NQGKLPFAAA 340 QIGNAFRNEI 350 SPRSGLIRVR 360 EFTMAEIEHF 370 CDPNDKAHPK 380 FDSVKDTTLM 390 LYSACNQMDG 400 KSAEAVKIGD 410 AVEKGLVANQ 420 TLGYFMARIH 430 QFLVKVGVDS 440 AKLRFRQHMS 450 NEMAHYACDC 460 WDAECLTSYG 470 WVECVGCADR 480 SAFDLTQHTK 490 ATGVRLAAEK 500 KLPEPQTIDV 510 VEAMPNKGAL 520 GKEFKKEAKQ 530 VMDALSALDK 540 NAVDDLAKQL 550 AETNLYTLAV 560 DGKDVKLTKD 570 HVEVKKYQKT 580 VHVEEIIPNV 590 IEPSFGIGRI 600 MYAIFEHNFK 610 TREGDEQRTF 620 FSLPPVVAPY 630 KCSLLPLLNN 640 PDFTPIIKKL 650 SQNLLLLDVS 660 HKVDDSAGSI 670 GRRYARTDEI 680 AIPFGITIDF 690 DTLKDSTATL 700 RERDSCQQVR 710 IPLAELPDIV 720 KDLAIGRRRW 730 AEVEAKYPKQ GEVKE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004820	glycine-tRNA ligase activity
Molecular Function	GO:0016740	transferase activity
Biological Process	GO:0070150	mitochondrial glycyl-tRNA aminoacylation

Reference

[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.