Search Results
Overview
| Uniprot ID | A0A6J1SLR2 |
|---|---|
| Protein Name | Bifunctional purine biosynthesis protein ATIC |
| Gene Name | LOC113208865 |
| Organism | Frankliniella occidentalis |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | ALLSVSDKKGLIELA |
| 395 | EQMRNNAKIDGGLFK |
Function
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization
Protein Sequence
10
MAASGKLALL
20
SVSDKKGLIE
30
LAKDLHNLGL
40
TLVASGGTAT
50
AVRNAGLPVK
60
DVSDITGAPE
70
MLGGRVKTLH
80
PAVHAGILSR
90
LSDSDKADMS
100
KQNYEMIRVV
110
VCNLYPFVDT
120
VSKPNVTIAD
130
AVENIDIGGV
140
TLLRAAAKNH
150
DRVTVICDPS
160
DYEKVVKEMK
170
NSSDKDTSKN
180
TRQTLALKAF
190
THTSEYDLAI
200
TDYFRKQYSA
210
GESQMTLRYG
220
MNPHQKPAQL
230
FTTLAELPLK
240
VVNGSPGFIN
250
LCDALNGWQL
260
VKELKTAIGL
270
PAATSFKHVS
280
PAGAAVGNPL
290
SPEQAKLCMV
300
EDLSNELTPL
310
AIAYARARGA
320
DRMSSFGDFI
330
ALSDVCDAVT
340
ARIISREVSD
350
GIIAPGYSPE
360
ALEILKKKKN
370
GGYCVLSIDP
380
SYEPAALERR
390
VLFGLTMEQM
400
RNNAKIDGGL
410
FKNVVSKKKD
420
LPESAVRDLI
430
IATITLKYTQ
440
SNSVCYARDG
450
QVIGIGAGQQ
460
SRIHCTRLAG
470
DKADNWWLRQ
480
HPTVLKMNFK
490
KGTKRAEISN
500
AIDNFVNGSV
510
GKDMDRTLFE
520
SQFETVPVDL
530
TQDERSAWAR
540
KLSGVALASD
550
AFFPFRDNVD
560
RASLSGVSFI
570
GSPSGSNNDE
580
EVLKACDEHG
590
IILCHTNLRL
FHH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003937 | IMP cyclohydrolase activity |
| Molecular Function | GO:0004643 | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| Biological Process | GO:0006189 | 'de novo' IMP biosynthetic process |
Reference
[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.