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Overview

Uniprot ID	A0A6J1SYY3
Protein Name	Sodium/potassium-transporting ATPase subunit alpha
Gene Name	LOC113210068
Organism	Frankliniella occidentalis

Kla Sites from experimental identification

Position	Flanking peptide
416	LCNRAQFKGGQQGVP
426	QQGVPVLKREVNGDA

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients

Protein Sequence

10 MPKEKKTKRK 20 TETLDDLKKE 30 LEIDFHKITL 40 DELCHRFQTD 50 PNRGLTPAKA 60 KEVLERDGPN 70 ALTPPKTTPE 80 WVKFCQQLFG 90 GFSMLLWIGA 100 ILCFVAYAIE 110 WTQTDEPTED 120 NLYLSITLAA 130 VVIVTAIFSY 140 YQESKSSKIM 150 DSFKNMVPQT 160 AVVIRGGETL 170 TMKAEEIVVG 180 DLVEVKFGDR 190 IPADIRVVEA 200 RSFKVDNSSL 210 TGESEPQART 220 AEYTHENPLE 230 TKNLAFFSTN 240 AVEGTARGIV 250 ICTANDTVMG 260 RIAGLASGLE 270 TGEAPIAKEI 280 HHFITLITGV 290 AVFLGVSFFI 300 ISFILGYHWL 310 EAVVFLIGII 320 VANVPEGLLA 330 TVTVCLTLTA 340 KRMASKNCLV 350 KNLEAVETLG 360 STSTICSDKT 370 GTLTQNRMTV 380 AHMWFDNQII 390 EADTTEDQTG 400 VQYDKSSEGF 410 KALARVGCLC 420 NRAQFKGGQQ 430 GVPVLKREVN 440 GDASESAILK 450 CMELALGDVQ 460 AIRNRNKKVC 470 EIPFNSTNKF 480 QVSIHENEDK 490 NDNRHILVMK 500 GAPERILEVS 510 SSIFMNGKDL 520 PLDEELKIAF 530 NSAYLELGGL 540 GERVLGFCDF 550 MLPAEQFPKG 560 FKFDADSPNF 570 PLTGFRFVGL 580 MSMIDPPRAT 590 VPDAVVKCRS 600 AGIKVIMVTG 610 DHPITAKAIA 620 KSVGIISDGN 630 ETVEDIAERL 640 GIDVHDVNPR 650 DAKAAVIHGM 660 ELRHLNSDQL 670 DEILKNHSEI 680 VFARTSPQQK 690 LIIVEGCQRL 700 GAIVAVTGDG 710 VNDSPALKKA 720 DIGVAMGIAG 730 SDVSKQAADM 740 ILLDDNFASI 750 VTGVEEGRLI 760 FDNLKKSIAY 770 TLSSNIPEIS 780 PFLMFILVGI 790 PLPLGTITIL 800 CIDLGTDMVP 810 AISLAYEEAE 820 SDIMKRPPRN 830 PFLASDKLVN 840 SRLISMSYAQ 850 IGMIQAVGGF 860 FMYFVIMAQN 870 GFLPYHLIGI 880 RKQWDSKSVN 890 DLPDSYGQEW 900 TYRDRKRLEY 910 TCQTAFFVAI 920 VIVQWADLII 930 CKTRRNSLFT 940 QGMRNWALNF 950 GLIFETVLAA 960 FLSYTPGMDK 970 GLRMYPLHWS 980 WWFVPLPFMV 990 SILIYDETRK 1000 FILRRRPGGW LERETYY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0090533	cation-transporting ATPase complex
Cellular Component	GO:0098797	plasma membrane protein complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0005391	P-type sodium:potassium-exchanging transporter activity
Biological Process	GO:0030007	intracellular potassium ion homeostasis
Biological Process	GO:0006883	intracellular sodium ion homeostasis
Biological Process	GO:1990573	potassium ion import across plasma membrane
Biological Process	GO:1902600	proton transmembrane transport
Biological Process	GO:0036376	sodium ion export across plasma membrane

Reference

[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.