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Overview

Uniprot IDA0A6J1T051
Protein NameSterol carrier protein 2
Gene NameLOC113212065
OrganismFrankliniella occidentalis

Kla Sites from experimental identification

Position Flanking peptide
123 ERGSLSSKFFDRTNP
443 DKDNLIEKFRGTYGF
451 FRGTYGFKVKNGPGG
479 GSVDFNSKAKADVTF

Function

Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs

Protein Sequence

10 MSPKRVFVVG 20 VGMTKFEKPG 30 RREDFDYPQM 40 AKEAVTKALD 50 DARLRVEDIN 60 QACVGYVYGD 70 STCGQRALYE 80 VGMTGMPVYN 90 VNNNCSTGST 100 ALLLAKQIVE 110 AGSGECVLAL 120 GFEKMERGSL 130 SSKFFDRTNP 140 MDKHVEVMAD 150 IAGMDGSPIT 160 AQLFGNAGKE 170 HMAKYGTKPE 180 HFAKIAYKNH 190 KHSVNNPYSQ 200 FQDAYTLDQI 210 MQSPQIFGPL 220 TKLQCCPTSD 230 GAAAAILCSE 240 DFVHRHGLEA 250 QAVEIVGMEM 260 STDLPSTFKD 270 NSCMKIVGYD 280 MTKNAADRLF 290 VKTNLKPQDV 300 DVVELHDCFS 310 ANELITYEAL 320 GLCPPGKAGE 330 LIDAGGNTYG 340 GKFVVNPSGG 350 LISKGHPLGA 360 TGIAQCSELC 370 WQVRGLAEKR 380 QVPGAKLGLQ 390 HNIGLGGAVI 400 VALYRLGFPH 410 YARSAVGLNT 420 VSASANPDDF 430 KASILFKALE 440 LAMADDKDNL 450 IEKFRGTYGF 460 KVKNGPGGAE 470 GFWLINAKTG 480 KGSVDFNSKA 490 KADVTFIMDD 500 KDVPDLITGK 510 LNPQKAFFQG 520 KIKIQGNMGL 530 AMKLTELQKK 540 AASRIDEFRS KL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0003988 acetyl-CoA C-acyltransferase activity
Molecular Function GO:0050633 acetyl-CoA C-myristoyltransferase activity
Molecular Function GO:0008289 lipid binding
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0006869 lipid transport

Reference

[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.