Search Results
Overview
| Uniprot ID | A0A6J1T5C4 |
|---|---|
| Protein Name | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| Gene Name | LOC113213820 |
| Organism | Frankliniella occidentalis |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 294 | SGIMEFRKLNQEAFQ |
| 465 | REAVLFLKKIKAAVE |
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A
Protein Sequence
10
MLSISRNVHR
20
SIHGITSKIV
30
NSNNSKVAQR
40
LFRQVRTAHE
50
DAHARVCVLP
60
SSKCLSICHP
70
PSHQSKWALQ
80
SRTFQTSHSL
90
CQESRVVNCP
100
AFPESVSEGD
110
IRWEKAVGDQ
120
VSEDEVVCEI
130
ETDKTSVPVA
140
SPANGTIEEL
150
LVEDGATVKA
160
GVPLFKLKLG
170
GAGSAKKEAP
180
AAAAPSPAAA
190
APPPPPPPQP
200
TAAAPPPPPA
210
AAAPPPPPPP
220
PPQAPLSSIP
230
VAAIRHAQAI
240
EAATVKVPPA
250
DPTKEISGTR
260
TEQRVKMNRM
270
RLRIAQRLKD
280
AQNVNAMLTT
290
FNELDMSGIM
300
EFRKLNQEAF
310
QKKHGIKLGF
320
MSAFVKAAAY
330
ALQEQPVVNA
340
VIDGQEIVYR
350
DYIDISVAVA
360
TPKGLVVPVI
370
RNVETMNYAE
380
IEHSMNNLAE
390
KARKNALAVE
400
DMDGGTFTIS
410
NGGVFGSLMG
420
TPIINPPQSA
430
ILGMHGTFER
440
PVAIKGQVVI
450
RPMMYIALTY
460
DHRLIDGREA
470
VLFLKKIKAA
480
VEDPRIIVAG
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045252 | oxoglutarate dehydrogenase complex |
| Molecular Function | GO:0004149 | dihydrolipoyllysine-residue succinyltransferase activity |
| Biological Process | GO:0033512 | L-lysine catabolic process to acetyl-CoA via L-saccharopine |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.