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Overview

Uniprot IDA0A6J1T890
Protein NameCoatomer subunit alpha
Gene NameLOC113212400
OrganismFrankliniella occidentalis

Kla Sites from experimental identification

Position Flanking peptide
76 GGDDYKIKVWNYKQK

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MLTKFETKSA 20 RVKGLSFHPK 30 RPWVLSSLHN 40 GVIQLWDYRM 50 CTLLEKFDEH 60 DGPVRGICFH 70 SQQPLFVSGG 80 DDYKIKVWNY 90 KQKRCIFTLL 100 GHLDYIRTTV 110 FHHEYPWILS 120 ASDDQTIRIW 130 NWQSRTCICV 140 LTGHAHYVMC 150 AQFHPSEDLV 160 VSASLDQTVR 170 VWDISGLRKK 180 NVAPGPGGLE 190 EHLRNPNATD 200 LFGQADAVVK 210 HVLEGHDRGV 220 NWAAFHPTLP 230 LIVSGADDRL 240 IKMWRMNESK 250 AWQVDTCRGH 260 YNNVSCVLFH 270 PRQELILSNS 280 EDKSIRVWDA 290 TKRSCLHTFR 300 REHERFWVLA 310 AHPTLNLFAA 320 GHDSGMIIFK 330 LERERPAYAV 340 HGNFLYYVKD 350 RFLRRLDLTA 360 SKDITLMQLR 370 GGGRTPVYSM 380 SYNPAENAVL 390 LCTRTSNVET 400 STYDLYVIPK 410 ETDSQNPEAP 420 DSKRASGITA 430 IWVARNRFAV 440 LDRTHALVIK 450 NLKNEVTKKV 460 QTPACDEIFY 470 AGTGMLLLRD 480 PDAITLFDVQ 490 QKRTLSQVKI 500 SKCRYVVWSA 510 DMSLVALLAK 520 HTVLICTRRL 530 ETKCSIHENT 540 RVKSGAWTDD 550 GIFIYTTSNH 560 IKYALSNGDH 570 GIIRTLDMPI 580 YITQVKGNQV 590 FNLDRECRPR 600 VMNIDPTEFK 610 FKLALINRNY 620 DEVLHMVRNA 630 RLVGQSIIAY 640 LQQKGYPEVA 650 LHFVKDEMTR 660 FGLALECGNI 670 EVAVESARAL 680 DDKHCWECLG 690 EAALLQGNHQ 700 VVEMCYQRTK 710 NFDKLAFLYL 720 ITGNLEKLRK 730 MTKIAEIRKD 740 CMGQYQGALY 750 LGDIAERVKV 760 LKPTQPSLAY 770 LTAATHGLEE 780 EAEQMKEQLL 790 SAGKKLPELN 800 PDAMLIRPPA 810 PILQAESNWP 820 LLTVTKGFFE 830 GAMGNRTTNA 840 ASAALAAVPV 850 EGDVEAEGWD 860 TDPEVGEEGD 870 GEEGAVEGGE 880 GGTGWDEGDD 890 DLELPPELEE 900 TLPAAAEEGY 910 FVAPTKGSSQ 920 GQLWVNNSQL 930 AVDHILAGSF 940 ESAFRLLHDQ 950 VGVVNFNAYE 960 SVFMSTFSRA 970 RASYPAFPMT 980 GSIYRHLQRS 990 WGDSGPKGGL 1000 PAVGLKLNDL 1010 VQRLQVCYQL 1020 TTGGKFIEAV 1030 EKFRALLLSI 1040 PLLVVDTKPD 1050 IVQAQALLQI 1060 CREYISGLMM 1070 ELLRKDLPKN 1080 TLEENKRNCE 1090 MAAYFTHCNL 1100 QPVHQILTLR 1110 TALKLFFKLK 1120 NFKTAGSFAR 1130 RLLELGPSPE 1140 LCQQAKKFLQ 1150 ACDMNPVDEH 1160 KLTYDEHNPF 1170 SLCGVTYKPI 1180 YRGKPEEKCP 1190 LCGTSYMPQY 1200 KGTVCTVCTV 1210 AEVGKDCLGL RISTIQFR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.