Search Results
Overview
| Uniprot ID | A0A6J1TQ85 |
|---|---|
| Protein Name | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial |
| Gene Name | LOC113217276 |
| Organism | Frankliniella occidentalis |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 124 | ENMGIKQKLFATLDE |
| 190 | DTSDETYKKMMEWGQ |
| 296 | NKMVKEGKLGVKSGE |
Function
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes
Protein Sequence
10
MAAVSQVLKR
20
SFSSSSPMAG
30
AIKNVTVIGG
40
GLMGSGIAQI
50
AAAAGQKVVL
60
VETNEKLLQG
70
ANSRINESLK
80
RVAKKQFKEN
90
PSAGESFVQE
100
TMGRISGTTN
110
PSEGAASADL
120
IVEAIVENMG
130
IKQKLFATLD
140
EAAPKHTIFA
150
SNTSSLSITE
160
IASQCQRKDK
170
FGGLHFFNPV
180
PVMKLLEVVR
190
TNDTSDETYK
200
KMMEWGQEVG
210
KTCITCKDTP
220
GFVVNRLLVP
230
QLAEAIRMLE
240
RGDASPRDID
250
TAMKLGAGHP
260
MGPFELADYV
270
GHDTTKFIID
280
GWHEKMPENP
290
LFKPSELLNK
300
MVKEGKLGVK
310
SGEGFYSYKK
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0003857 | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| Molecular Function | GO:0070403 | NAD+ binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.