Search Results
Overview
| Uniprot ID | A0A6Q8PFJ0 |
|---|---|
| Protein Name | Prelamin-A/C |
| Gene Name | LMNA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 341 | SRRLLAEKEREMAEM |
Function
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence
Protein Sequence
10
METPSQRRAT
20
RSGAQASSTP
30
LSPTRITRLQ
40
EKEDLQELND
50
RLAVYIDRVR
60
SLETENAGLR
70
LRITESEEVV
80
SREVSGIKAA
90
YEAELGDARK
100
TLDSVAKERA
110
RLQLELSKVR
120
EEFKELKARN
130
TKKEGDLIAA
140
QARLKDLEAL
150
LNSKEAALST
160
ALSEKRTLEG
170
ELHDLRGQVA
180
KLEAALGEAK
190
KQLQDEMLRR
200
VDAENRLQTM
210
KEELDFQKNI
220
YSEELRETKR
230
RHETRLVEID
240
NGKQREFESR
250
LADALQELRA
260
QHEDQVEQYK
270
KELEKTYSAK
280
LDNARQSAER
290
NSNLVGAAHE
300
ELQQSRIRID
310
SLSAQLSQLQ
320
KQLAAKEAKL
330
RDLEDSLARE
340
RDTSRRLLAE
350
KEREMAEMRA
360
RMQQQLDEYQ
370
ELLDIKLALD
380
MEIHAYRKLL
390
EGEEERLRLS
400
PSPTSQRSRG
410
RASSHSSQTQ
420
GGGSVTKKRK
430
LESTESRSSF
440
SQHARTSGRV
450
AVEEVDEEGK
460
FVRLRNKSNE
470
DQSMGNWQIK
480
RQNGDDPLLT
490
YRFPPKFTLK
500
AGQVVTIWAA
510
GAGATHSPPT
520
DLVWKAQNTW
530
GCGNSLRTAL
540
INSTGEEVAM
550
RKLVRSVTVV
560
EDDEDEDGDD
570
LLHHHHGSHC
580
SSSGDPAEYN
590
LRSRTVLCGT
600
CGQPADKASA
610
SGSGAQVGGP
620
ISSGSSASSV
630
TVTRSYRSVG
640
GSGGGSFGDN
650
LVTRSYLLGN
660
SSPRTQVSCL
670
CFVSKSCRRV
680
PGHRGVGRGG
690
LAGGRACLLF
700
RSPGEWEPPP
710
HSLSPRQPTS
720
ASCPSCLSPR
LEGRGRAGV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0005652 | nuclear lamina |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0016607 | nuclear speck |
| Biological Process | GO:0006998 | nuclear envelope organization |
Reference
PMID: N/A