Search Results
Overview
| Uniprot ID | A0A8D0MDT2 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha |
| Gene Name | CAPZA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | TALRAYVKEHYPNGV |
| 125 | GVCTVYGKKIDGQQT |
| 126 | VCTVYGKKIDGQQTI |
| 247 | QLPVTRTKIDWNKIL |
| 70 | NGKFLDPKNRICFKF |
| 76 | PKNRICFKFDHLRKE |
| 82 | FKFDHLRKEATDPRP |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments
Protein Sequence
10
TLKAGCHSSV
20
FKKLYQCNIY
30
NFHKINNGES
40
HAFAQYNLDQ
50
FTPVKIEGYE
60
DQVLITEHGD
70
LGNGKFLDPK
80
NRICFKFDHL
90
RKEATDPRPY
100
EAENAVESWR
110
TSVETALRAY
120
VKEHYPNGVC
130
TVYGKKIDGQ
140
QTIIACIESH
150
QFQAKNFWNG
160
RWRSEWKFTI
170
TPSTTQVVGI
180
LKIQVHYYED
190
GNVQLVSHKD
200
IQDSLTVSNE
210
VQTAKEFIKI
220
VEAAENEYQT
230
AISENYQTMS
240
DTTFKALRRQ
250
LPVTRTKIDW
260
NKILSYKIGK
EMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.