Overview
| Uniprot ID | A0A8D0MG08 |
|---|
| Protein Name | ATP synthase subunit b |
|---|
| Gene Name | ATP5PB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 127 |
ADKLNEQKIAQLEEV |
| 135 |
IAQLEEVKQASIKQI |
| 140 |
EVKQASIKQIQDAID |
| 158 |
SQQALVQKRHYLFDV |
| 217 |
HMIRWVEKHVVQSIS |
| 229 |
SISAQQEKETIAKCI |
| 234 |
QEKETIAKCIADLKL |
| 240 |
AKCIADLKLLAKKAQ |
Function
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
Protein Sequence
10
YQKPFPLFPH
20
FSLAPSLHFS
30
SWDLTATRIF
40
HTGQPSLAPV
50
PPLPEHGGKV
60
RLGLIPEEFF
70
QFLYPKTGVT
80
GPYVLGTGLI
90
LYLLSKEIYV
100
ITAETFSAIS
110
TIGVLVYIVK
120
KYGASIGAFA
130
DKLNEQKIAQ
140
LEEVKQASIK
150
QIQDAIDLEK
160
SQQALVQKRH
170
YLFDVQRNNI
180
AMALEVTYRE
190
RLHRVYKEIK
200
NRLDYHISVQ
210
NMMRQKEQEH
220
MIRWVEKHVV
230
QSISAQQEKE
240
TIAKCIADLK
250
LLAKKAQAQP
VL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0015078 |
proton transmembrane transporter activity |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.