Overview
| Uniprot ID | A0A8D0MLF8 |
|---|
| Protein Name | Large ribosomal subunit protein uL13 |
|---|
| Gene Name | RPL13A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 118 |
VRLKPTRKFAYLGRL |
| 132 |
LAHEVGWKYQAVTAT |
| 143 |
VTATLEEKRKEKAKI |
| 54 |
NFYRNKLKYLAFLRN |
| 87 |
QAALDRLKVFDGIPP |
| 98 |
GIPPPYDKKKRMVVP |
Function
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA
Protein Sequence
10
MAEGQQVLVL
20
DGRGHLLGRL
30
AAIVAKQVLL
40
GRKVVVVRCE
50
GINISGNFYR
60
NKLKYLAFLR
70
NRIFWRTVRG
80
MLPHKTKRGQ
90
AALDRLKVFD
100
GIPPPYDKKK
110
RMVVPAALKV
120
VRLKPTRKFA
130
YLGRLAHEVG
140
WKYQAVTATL
150
EEKRKEKAKI
160
HYRKKKQLMR
170
LRKQAEKNVE
180
KKIDRFTEVL
KTHGFLV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0022625 |
cytosolic large ribosomal subunit |
| Cellular Component |
GO:0097452 |
GAIT complex |
| Cellular Component |
GO:0005840 |
ribosome |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:1901194 |
negative regulation of formation of translation preinitiation complex |
| Biological Process |
GO:0017148 |
negative regulation of translation |
| Biological Process |
GO:0006412 |
translation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.