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Overview

Uniprot IDA0A8D0N8D4
Protein NameNuclear receptor coactivator 5
Gene NameNCOA5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
139 MDDYCRRKDDSYFDR

Function

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)

Protein Sequence

10 INTGPQDPYG 20 FGDSRDTRRD 30 RSPIRGSPRR 40 EPRDGRNGRD 50 ARDSRDMRDM 60 RDMRDPRDLR 70 DHRDSRDMRD 80 HRDSRSMRDA 90 RDLRDLRDFR 100 DLRDSRDFRD 110 HRDPMYDRYR 120 DMRDSRDPMY 130 RREGSYDRYL 140 RMDDYCRRKD 150 DSYFDRYRDS 160 FDGRGPPGPE 170 NQSRAKERLK 180 REERRREELY 190 RQYFEEIQRR 200 FDAERPVDCS 210 VIVVNKQTKD 220 YAESVGRKVR 230 DLGMVVDLIF 240 LNTEVSLSQA 250 LEDVSRGGSP 260 FAIVITQQHQ 270 IHRSCTVNIM 280 FGTPQEHRNM 290 PQADAMVLVA 300 RNYERYKNEC 310 REKEREEIAR 320 QAAKMADEAI 330 LQERERGGPD 340 EGMRGGHPPA 350 IQSLINLLAD 360 NRYLTAEETD 370 KIINYLRERK 380 ERLMRSSTDS 390 LPGPISRQPL 400 GASSGASLKT 410 QPSSQPLQSG 420 QVLPSATPTP 430 AAAPTSQQEL 440 QAKILSLFNS 450 GTVAANSSSA 460 SPSVAAGNTQ 470 NQNFSTAANS 480 QPQQRSQASG 490 NQPPNILGQA 500 GSARNMGPRP 510 GAPSQGLFGQ 520 PSTRLAPASN 530 LASQRPVSST 540 AINFDNPSVQ 550 KALDTLIQSG 560 PALSHLVSQT 570 TAQVGRPQAP MGSYQRHY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.