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Overview

Uniprot IDA0A8D0NPF0
Protein NameATP-citrate synthase
Gene NameACLY
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1007 MGIGHRVKSINNPDM
1020 DMRVQILKDYVRQHF
1109 YLDQKRLKQGLYRHP
12 AISEQTGKELLYKYI
166 KLNPEAIKKHLLVHA
167 LNPEAIKKHLLVHAP
230 ATADYICKVKWGDIE
272 KLTLLNPKGRIWTMV
369 RDYQGPLKEHEVTIF
4 ****MSAKAISEQTG
468 ADEVAPAKKAKPAMP
527 TLFSRHTKAIVWGMQ
569 FTGDHKQKFYWGHKE
645 LIKKAEQKGVTIIGP
809 IAKNQALKEAGVFVP
97 GQEATVGKARGFLKN

Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

Protein Sequence

10 MSAKAISEQT 20 GKELLYKYIC 30 TTSAIQNRFK 40 YARVTPDTDW 50 ARLLQDHPWL 60 LSESLVVKPD 70 QLIKRRGKLG 80 LVGVNLTLDG 90 VKSWLKPRLG 100 QEATVGKARG 110 FLKNFLIEPF 120 VPHSQEEEFY 130 VCIYAARDGD 140 HVLFHHEGGV 150 DVGDVDAKAQ 160 RLLVGVDEKL 170 NPEAIKKHLL 180 VHAPEDKKEI 190 LASFISGLFN 200 FYEDLYFTYL 210 EINPLVVTKD 220 GVYVLDLAAK 230 VDATADYICK 240 VKWGDIEFPP 250 PFGREAYPEE 260 AYIADLDAKS 270 GASLKLTLLN 280 PKGRIWTMVA 290 GGGASVVYSD 300 TICDLGGVNE 310 LANYGEYSGA 320 PSEQQTYDYA 330 KTILSLMTRE 340 KHPEGKILII 350 GGSIANFTNV 360 AATFKGIVRA 370 IRDYQGPLKE 380 HEVTIFVRRG 390 GPNYQEGLRV 400 MGEVGKTTGI 410 PIHVFGTETH 420 MTAIVGMALG 430 HRPIPNQPPT 440 AAHTANFLLN 450 ASGSTSTPAP 460 SRTASFSESR 470 ADEVAPAKKA 480 KPAMPQDSVP 490 SPRSLQGRTP 500 PVPPSSLCGL 510 VAGDSLTVCF 520 VSPSPGKSAT 530 LFSRHTKAIV 540 WGMQTRAVQG 550 MLDFDYVCSR 560 DEPSVAAMVY 570 PFTGDHKQKF 580 YWGHKEILIP 590 VFKNMADAMK 600 KHPEVDVLIN 610 FASLRSAYDS 620 TMETMNYAQI 630 RTIAIIAEGI 640 PEALTRKLIK 650 KAEQKGVTII 660 GPATVGGIKP 670 GCFKIGNTGG 680 MLDNILASKL 690 YRPGSVAYVS 700 RSGGMSNELN 710 NIISRTTDGV 720 YEGVAIGGDR 730 YPGSTFMDHV 740 LRYQDTPGVK 750 MIVVLGEIGG 760 TEEYKICRGI 770 KEGRITKPVV 780 CWCIGTCATM 790 FSSEVQFGHA 800 GACANQASET 810 AIAKNQALKE 820 AGVFVPRSFD 830 ELGEIIQSVY 840 EDLVSRGVIV 850 PAQEVPPPTV 860 PMDYSWAREL 870 GLIRKPASFM 880 TSICDERGQE 890 LIYAGMPITE 900 VFKEEMGIGG 910 VLGLLWFQKR 920 LPKYSCQFIE 930 MCLMVTADHG 940 PAVSGAHNTI 950 ICARAGKDLV 960 SSLTSGLLTI 970 GDRFGGALDA 980 AAKMFSKAFD 990 SGIIPMEFVN 1000 KMKKEGKLIM 1010 GIGHRVKSIN 1020 NPDMRVQILK 1030 DYVRQHFPAT 1040 PLLDYALEVE 1050 KITTSKKPNL 1060 ILNVDGLIGV 1070 AFVDMLRNCG 1080 SFTREEADEY 1090 IDIGALNGIF 1100 VLGRSMGFIG 1110 HYLDQKRLKQ 1120 GLYRHPWDDI 1130 SYVLPEHMSM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003878 ATP citrate synthase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006085 acetyl-CoA biosynthetic process
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0110076 negative regulation of ferroptosis
Biological Process GO:0006107 oxaloacetate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.