Search Results
Overview
| Uniprot ID | A0A8D0PDF1 |
|---|---|
| Protein Name | Lactoylglutathione lyase |
| Gene Name | GLO1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 140 | PDVHGACKRFEELGV |
| 148 | RFEELGVKFVKKPDD |
| 151 | ELGVKFVKKPDDGKM |
| 96 | AAWAFSRKATLELTH |
Function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis
Protein Sequence
10
MAEPQLASSG
20
LTDEAALACC
30
SDPDPSTKDF
40
LFQQTMLRIK
50
DPKKSLDFYT
60
RILGMTLLQK
70
LDFPTMKFSL
80
YFLAYEDKND
90
IPKDKSEKAA
100
WAFSRKATLE
110
LTHNWGTEDD
120
ESQSYHSGNS
130
DPRGFGHIGI
140
AVPDVHGACK
150
RFEELGVKFV
160
KKPDDGKMKG
170
LAFIQDPDGY
180
WIEILNPNNM
ITII
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004462 | lactoylglutathione lyase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030316 | osteoclast differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.