Overview
| Uniprot ID | A0A8D0QQ23 |
|---|
| Protein Name | Calumenin |
|---|
| Gene Name | CALU |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 342 |
VYESDQNKDGKLTKE |
Function
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion
Protein Sequence
10
MDLRHFLMCL
20
SLCTAFALSK
30
PTEKKDRVHH
40
EPQLSDKVHN
50
DAQSFDYDHD
60
AFLGAEEAKT
70
FDQLTPEESK
80
ERLGKIVSKI
90
DGDKDGFVTV
100
DELKDWIKFA
110
QKRWIYEDVE
120
RQWKGHDLNE
130
DGLVSWEEYK
140
NATYGYVLDK
150
IDADKDGFVT
160
EGELKSWIKH
170
AQKKYIYDNV
180
ENQWQEFDMN
190
QDGLISWDEY
200
RNVTYGTYLD
210
DPDPDDGFNY
220
KQMMVRDERR
230
FKMADKDGDL
240
IATKEEFTAF
250
LHPEEYDYMK
260
DIVVQETMED
270
IDKNADGFID
280
LEEYIGDMYS
290
HDGNADEPEW
300
VKTEREQFVE
310
FRDKNRDGKM
320
DKEETKDWIL
330
PSDYDHAEAE
340
ARHLVYESDQ
350
NKDGKLTKEE
360
IVDKYDLFVG
370
SQATDFGEAL
VRHDEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.