Overview
| Uniprot ID | A0A8D0RU74 |
|---|
| Protein Name | Mitochondrial carrier homolog 2 |
|---|
| Gene Name | MTCH2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 131 |
QHYQECDKVEETGSG |
| 153 |
SSFDRVIKETTREMM |
Function
Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins. Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Regulates the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology
Protein Sequence
10
MADAASQVLL
20
GSGLTILSQP
30
LMYVKVLIQG
40
QLPPRAELPL
50
ALGLPEISPR
60
GQVGRPSPFP
70
VGYEPLPPTI
80
GRNIFGRQVC
90
QLPGLFCYAQ
100
HIASIDGKRG
110
LFTGLTPRLC
120
SGVLGTVVHG
130
KVLQHYQECD
140
KVEETGSGNV
150
QKEVSSSFDR
160
VIKETTREMM
170
ARSAATLITH
180
PFHVITLRSM
190
VQFIGRESKY
200
CGLCDSIVTI
210
YREEGILGFF
220
AGLIPRLLGD
230
IISLWLCNSL
240
AYLVNTYALD
250
SGVSTMNEMK
260
SYSQAVTGFF
270
ASMLTYPFVL
280
VSNLMAVNNC
290
GLAGGSPPYS
300
PIYTSWIDCW
310
CMLQKEGNMS
320
RGNSLFFRKV
330
PFGKTYCCDL
RMLI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Biological Process |
GO:0090151 |
establishment of protein localization to mitochondrial membrane |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0070585 |
protein localization to mitochondrion |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.