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Overview

Uniprot IDA0A8D0S0Y6
Protein NameNon-histone chromosomal protein HMG-17
Gene NameHMGN2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
19 KGDKAKVKDEPQRRS
32 RSARLSAKPAPPKPE
65 KGKADAGKDGNNPAE
83 AKTDQAQKAEGAGDA

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation

Protein Sequence

10 MLQTPFAEGD 20 AKGDKAKVKD 30 EPQRRSARLS 40 AKPAPPKPEP 50 KPKKAPAKKG 60 EKVPKGKKGK 70 ADAGKDGNNP 80 AENGDAKTDQ 90 AQKAEGAGDA K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0031492 nucleosomal DNA binding
Biological Process GO:0006325 chromatin organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.