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Overview

Uniprot ID	A0A8D0T5R5
Protein Name	Ubiquitin conjugation factor E4
Gene Name	UBE4B
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1010	KSTIAIEKFKLLAEK

Function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates

Protein Sequence

10 MEELSADEIR 20 RRRLARLAGG 30 QTSQPTTPLT 40 SPQRENPPGP 50 PIAASAPGPS 60 QSLGLNVHSM 70 TPATSPIGAS 80 GVAHRSQSSE 90 GVSSLSSSPS 100 NSLETQSQSL 110 SRSQSMDIDG 120 VSCEKSLSQV 130 DVDSGIENME 140 VDENDRREKR 150 SLSDKEPSSG 160 SEVSEEQALQ 170 LVCKILRVSW 180 KDRDRDVIFL 190 SSLSAQFKQN 200 PKEVFSDFKD 210 LIGQILMEVL 220 MMSTQTRDEN 230 PFASLTATSQ 240 PIAAAARSPD 250 RNLLLNAGSN 260 PGTSPMFCSA 270 GSFGASSLSS 280 LGASGGASTW 290 DSYSDHFTIE 300 TCKETDMLNY 310 LIECFDRVGI 320 EEKKAPKMCS 330 QPAVSQLLSN 340 IRSQCISHTA 350 LVLQGSLTQP 360 RSMQQPSFLV 370 PYMLCRNLPY 380 GFIQELVRTT 390 HQDEEVFKQI 400 FIPILQGLAL 410 AAKECSLDSD 420 YFKYPLMALG 430 ELCETKFGKT 440 HPVCNLVASL 450 PLWLPKSLSP 460 GSGRELQRLS 470 YLGAFFSFSV 480 FAEDDAKVVE 490 KYFSGPAITL 500 ENTRVVSQSL 510 QHYLELGRQE 520 LFKILHSILL 530 NGETREAALG 540 YMAAVVNANM 550 KKAQMQTDDR 560 LVSTDGFMLN 570 FLWVLQQLST 580 KIKLETVDPT 590 YIFHPRCRIT 600 LPNDETRVNA 610 TMEDVNDWLT 620 ELYGDQPPYS 630 EPKFPTECFF 640 LTLHAHHLSI 650 LPSCRRYIRR 660 LRAIRELNRT 670 VEDLKNNESQ 680 WKDSPLATRH 690 REMLKRCKTQ 700 LKKLVRCKAC 710 ADAGLLDESF 720 LRRCLNFYGL 730 LIQLLLRILD 740 PAYPDVTLPL 750 NSDVPKVFAA 760 LPEFYVEDVA 770 EFLFFIVQYS 780 PQVLYEPCTQ 790 DIVMFLVVML 800 CNQNYIRNPY 810 LVAKLVEVMF 820 MTNPAVQPRT 830 QKFFEMIENH 840 PLSTKLLVPS 850 LMKFYTDVEH 860 TGATSEFYDK 870 FTIRYHISTI 880 FKSLWQNLAH 890 HGTFMDEFNS 900 GKQFVRYINM 910 LINDTTFLLD 920 ESLESLKRIH 930 EVQEEMKNKE 940 QWDQLPRDQQ 950 QARQSQLAQD 960 ERVSRSYLAL 970 ATETVDMFHI 980 LTKQVQKPFL 990 RPRSYSKELF 1000 EEVISKMRKA 1010 GIKSTIAIEK 1020 FKLLAEKVEE 1030 IVAKNARAEI 1040 DYSDAPDEFR 1050 DPLMDTLMTD 1060 PVRLPSGTIM 1070 DRSIILRHLL 1080 NSPTDPFNRQ 1090 TLTESMLEPV 1100 PELKEQIHAW MREKQNSDH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000151	ubiquitin ligase complex
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity
Biological Process	GO:0036503	ERAD pathway
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.