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Overview

Uniprot IDA0A8D0U7I8
Protein NameCoatomer subunit beta'
Gene NameCOPB2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
122 ASLDRTIKVWQLGSS
166 GADDRLVKIWDYQNK
272 NGKIIWAKHSEVQQA
367 RESNSVVKIFKNFKE
581 RVAHFLEKQGFKQQA
625 AESEQKWKQLAELAI
733 LWRENLSKVNQKAAE
776 HADLWPAKQYPLVTP
84 IKLWDWDKKWSCSQV

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 MTLVKTFEVC 20 DLPVRAAKFV 30 ARKNWVVTGA 40 DDMQIRVFNY 50 NTLERVHMFE 60 AHSDYIRCIA 70 VHPTQPFILT 80 SSDDMLIKLW 90 DWDKKWSCSQ 100 VFEGHTHYVM 110 QIVINPKDNN 120 QFASASLDRT 130 IKVWQLGSSS 140 PNFTLEGHEK 150 GVNCIDYYSG 160 GDKPYLISGA 170 DDRLVKIWDY 180 QNKTCVQTLE 190 GHAQNVSCAS 200 FHPELPIIIT 210 GSEDGTVRIW 220 HSSTYRLEST 230 LNYGMERVWC 240 VASLRGSNNV 250 ALGYDEGSII 260 VKLGREEPAM 270 SMDANGKIIW 280 AKHSEVQQAN 290 LKAMGDAEIK 300 DGERLPLAVK 310 DMGSCEIYPQ 320 TIQHNPNGRF 330 VVVCGDGEYI 340 IYTAMALRNK 350 SFGSAQEFAW 360 AHDSSEYAIR 370 ESNSVVKIFK 380 NFKEKKSFKP 390 DFGAESIYGG 400 FLLGVRSVNG 410 LAFYDWDNTE 420 LIRRIEIQPK 430 HIFWSDSGEL 440 VCIATEESFF 450 ILKYLSEKVL 460 AAQETHEGVT 470 EDGIEDGFEV 480 LGEIQEIVKT 490 GLWVGDCFIY 500 TSSVNRLNYY 510 VGGEIVTIAH 520 LDRTMYLLGY 530 IPKDNRLYLG 540 DKELNIVSYS 550 LLVSVLEYQT 560 AVMRRDFSMA 570 DKVLPTIPKE 580 QRTRVAHFLE 590 KQGFKQQALT 600 VSTDPEHRFE 610 LALQLGELKI 620 AYQLAVEAES 630 EQKWKQLAEL 640 AISKCQFGLA 650 QECLHHAQDY 660 GGLLLLATAS 670 GNASMVNKLA 680 EGAERDGKNN 690 VAFMSYFLQG 700 KLDACLELLI 710 RTGRLPEAAF 720 LARTYLPSQV 730 SRVVKLWREN 740 LSKVNQKAAE 750 SLADPTEYEN 760 LFPGLKEAFV 770 VEEWVKETHA 780 DLWPAKQYPL 790 VTPNEERNVM 800 EEAKGFQPSR 810 SAAQQELAGK 820 PASPTPVIMA 830 THTGNKEEKS 840 LLELEVDLDN 850 LELEDIDTTD 860 INLDEDILDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030663 COPI-coated vesicle membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030117 membrane coat
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.