Overview
| Uniprot ID | A0A8D0UGU6 |
|---|
| Protein Name | Very-long-chain 3-oxoacyl-CoA reductase |
|---|
| Gene Name | HSD17B12 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 72 |
SYAEELAKRGMKIVL |
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation
Protein Sequence
10
METALPAAGF
20
LYWVGASTVA
30
YLALRISCWF
40
FTALRVWGLG
50
HEAGVGPWLG
60
EWAVVTGGTD
70
GIGKSYAEEL
80
AKRGMKIVLI
90
SRSQDKLDQV
100
SSEISEKFKV
110
ETKTIAVDFT
120
SEDIYDKIKA
130
SLAGLNIGVL
140
VNNVGMSYEY
150
PEYFLDVPDL
160
DNMTRLVLPG
170
MVERSKGAIL
180
NISSASGMYP
190
VPLLTIYSAT
200
KAFVDFFSQC
210
LHEEYKSKGV
220
IVQSVLPYYV
230
ATKLAKIKRP
240
TWDKPSPETF
250
VKSAMKTIGV
260
QSRTNGYPIH
270
SLVASVSASL
280
PSWLYFKIAM
290
YSGNSIRVRY
LKKMKMN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0141040 |
very-long-chain 3-oxoacyl-CoA reductase activity |
| Biological Process |
GO:0006694 |
steroid biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.