Search Results
Overview
| Uniprot ID | A0A8D0V0F1 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
| Gene Name | SUCLG1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 158 | VINPGECKIGIMPGH |
| 168 | IMPGHIHKKGRIGIV |
| 33 | LYVDKNTKVICQGFT |
| 69 | TTPGKGGKTHLGLPV |
Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase
Protein Sequence
10
LTYRSRPVFE
20
PNGIRHCSYT
30
ASRKHLYVDK
40
NTKVICQGFT
50
GKQGTFHSQQ
60
ALEYGTNLVG
70
GTTPGKGGKT
80
HLGLPVFNTV
90
KEAKEQTGAT
100
ASVIYVPPPF
110
AAAAINEAID
120
AEVPLVVCIT
130
EGIPQQDMVR
140
VKHRLLRQGK
150
TRLIGPNCPG
160
VINPGECKIG
170
IMPGHIHKKG
180
RIGIVSRSGT
190
LTYEAVHQTT
200
QVGLGQSLCV
210
GIGGDPFNGT
220
DFTDCLEIFL
230
NDPATEGIIL
240
IGEIGGNAEE
250
NAAEFLKQHN
260
SGPKSKPVVS
270
FIAGLTAPPG
280
RRMGHAGAII
290
AGGKGGAKEK
300
ITALQSAGVV
310
VSMSPAQLGT
320
TIYKVSATVA
WVL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.