Search Results

Overview

Uniprot IDA0A8D0VJ81
Protein NameNeutral alpha-glucosidase AB
Gene NameGANAB
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
303 HADSLRLKVTEGGDP
496 HLASKRRKLVAIVDP
51 AVDRSNFKTCEESSF
525 QNLGLYVKTRDGSDY
60 CEESSFCKRQRSIRP
933 VVIIGAGKPATVVLQ
942 ATVVLQTKGSPESRL

Function

Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia

Protein Sequence

10 GTFTSEGGAL 20 SDPVLIVPSL 30 SSPPRSWTGL 40 VLACLGVCLG 50 LTLAVDRSNF 60 KTCEESSFCK 70 RQRSIRPGQS 80 PYRALLDSLQ 90 LGPDTLTIHL 100 INEVTKVLLV 110 LELQGLQKNM 120 TRIRIDELEP 130 RRPRYRVPDV 140 LVAEPPTARL 150 SVSGQDDNSV 160 EVTVAEGPYK 170 IILTARPFRL 180 DLLEDRSLLL 190 SVNARGLLNF 200 EHQRAPRVSF 210 SDKVSLTLGS 220 IWDKIKNLFS 230 RQGSKDPAEG 240 DGAQPEEAPG 250 DGDKPEEIQG 260 KAEKDEPGAW 270 EETFKTHSDS 280 KPYGPTSVGL 290 DFSLPGMEHV 300 YGIPEHADSL 310 RLKVTEGGDP 320 YRLYNLDVFQ 330 YELYNPMALY 340 GSVPVLLAHS 350 PHRDLGIFWL 360 NAAETWVDIS 370 SNTAGKTLFG 380 KMLDYLQGSG 390 ETPQTDVRWM 400 SESGIIDVFL 410 LLGPSVFDVF 420 RQYASLTGTQ 430 ALPPLFSLGY 440 HQSRWNYRDE 450 ADVLEVNQGF 460 DDHNLPCDFI 470 WLDIEHADGK 480 RYFTWDPSRF 490 PQPRTMLEHL 500 ASKRRKLVAI 510 VDPHIKVDSS 520 YRVHEELQNL 530 GLYVKTRDGS 540 DYEGWCWPGA 550 ASYPDFTNPK 560 MRAWWADMFR 570 FENYEGSSSN 580 LYVWNDMNEP 590 SVFNGPEVTM 600 LKDAQHYGGW 610 EHRDLHNIYG 620 FYVHMATADG 630 LVLRSGGVER 640 PFVLSRAFFA 650 GSQRFGAVWT 660 GDNTAEWDHL 670 KISIPMCLSL 680 GLVGLSFCGA 690 DVGGFFKNPE 700 PELLVRWYQM 710 GAYQPFFRAH 720 AHLDTGRREP 730 WLLPTQYQDM 740 IRDALGQRYS 750 LLPFWYTLFY 760 QAHREGVPVM 770 RALWVHYPQD 780 VTTFSIDDEF 790 LLGDALLVHP 800 VTDSEAHGVQ 810 VYLPGQGEVW 820 YDVHSYQKYH 830 GPQTLYLPVT 840 LSSIPVFQRG 850 GTIVPRWMRV 860 RRSSDCMKDD 870 PITLFVALSP 880 QGTAQGELFL 890 DDGHTFNYQT 900 GHEFLLRRFS 910 FSGNTLVSSS 920 ADSKGHFETP 930 VWIERVVIIG 940 AGKPATVVLQ 950 TKGSPESRLS 960 FQHDPETSVL 970 ILRKPGVNVA SDWSIHLR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017177 glucosidase II complex
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0042470 melanosome
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Molecular Function GO:0033919 glucan 1,3-alpha-glucosidase activity
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006491 N-glycan processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.