Overview
| Uniprot ID | A0A8D1AHN7 |
|---|
| Protein Name | Galactose mutarotase |
|---|
| Gene Name | GALM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 227 |
CLKRSKEKQFCARVH |
| 266 |
LDGTLKGKTGAVYPK |
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Protein Sequence
10
MVSVTRSVFG
20
DLPSGAGTVE
30
KFQLQSDVVL
40
GFAELKEYLQ
50
KHPYFGAVVG
60
RVANRIAKGT
70
FTLDGKEYKL
80
AINNGPNSLH
90
GGVRGFDKVL
100
WTPRVLSNGI
110
EFSRVSPDGE
120
EGYPGELKVW
130
VTYTLDGGEL
140
VVNYRAQASQ
150
TTPVNLTNHS
160
YFNLAGQGSP
170
NIYDHEVTIE
180
ADAFLPVDET
190
LIPTGEIAPV
200
QGTAFDLRKP
210
VELGKHLQEF
220
HINGFDHNFC
230
LKRSKEKQFC
240
ARVHHAGSGR
250
VLEVYTTQPG
260
IQFYTGNFLD
270
GTLKGKTGAV
280
YPKHSGFCLE
290
TQNWPNAVNQ
300
PHFPPVLLKP
310
GEEYNHTTWF
VFSVA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0004034 |
aldose 1-epimerase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Biological Process |
GO:0006012 |
galactose metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.