Overview
| Uniprot ID | A0A8D1AXG3 |
|---|
| Protein Name | ATP synthase F(1) complex subunit delta, mitochondrial |
|---|
| Gene Name | ATP5F1D |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 147 |
VAKANLEKAQSELLG |
Function
Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate
Protein Sequence
10
GHRGQEGLST
20
RERDCLEIAP
30
DCPPQRTAPP
40
GGKDWWPCSG
50
ISENRVWGLE
60
DQQPRVGTVF
70
FNGANVRQVD
80
VPTQTGAFGI
90
LASHVPTLQV
100
LRPGLVVVHA
110
EDGTTSKYFV
120
SSGSVTVNAD
130
SSVQLLAEEA
140
VTLDMLDPGV
150
AKANLEKAQS
160
ELLGAADEAS
170
RAEIQIRIEA
NEALVKALE
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0046933 |
proton-transporting ATP synthase activity, rotational mechanism |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0033615 |
mitochondrial proton-transporting ATP synthase complex assembly |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.