Search Results

Overview

Uniprot IDA0A8D1B2D5
Protein NameAnkyrin repeat and FYVE domain-containing protein 1
Gene NameANKFY1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1129 IIKFDLNKPVRVCNI

Function

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI[3]P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. Required for podocyte migration

Protein Sequence

10 MAEEEVAKLE 20 KHLMLLRQEY 30 VKLQKKLAET 40 EKRCTLLAAQ 50 ANKESSSESF 60 ISRLLTIVAD 70 LYEQEQYSDL 80 KIKVGGRHIN 90 AHKFVLAARS 100 DSWSLASLSS 110 TEELDLSDAN 120 PEVTMTMLRW 130 IYTDELEFRE 140 DDVFLTELMK 150 LANRFQLQLL 160 RERCEKGVMS 170 LVNVRNCIRF 180 YQTAEELNAS 190 TLVNYCAEII 200 ASHWDDLRKE 210 DFSSMGAQLL 220 YKMIKSKTEY 230 PLHKAIKVER 240 EDVVFLYLIE 250 MDSQLPGKLN 260 ELDQNGDLAL 270 DLALSRRLES 280 IASTLVSHKA 290 DVDMVDKNGW 300 SLLHKGIQRG 310 DLFAATFLIK 320 NGALVNAATL 330 GAQETPLHLV 340 ASYSSEKHSA 350 GVMSEMAQIA 360 EALLQAGANP 370 NMQDSKGRLD 380 LELKDHEGST 390 ALWLAVQYIT 400 VSSDQSVNPF 410 EDLPVVNGTS 420 FDENSFAARL 430 IQRGSNTNAP 440 DTVTGNCLLQ 450 RAAEAGNEAA 460 ALFLATSGAH 470 VNHRNKWGET 480 PLHTACRHGL 490 ANLTAELLQQ 500 GANPNLQTEE 510 ALPSPKEAAS 520 LSGSADSSVS 530 QQTPLHMAIA 540 YNHPDVVSII 550 LEQKANALHA 560 TNNLQIIPDF 570 SLKDSRDQTV 580 LGLALWTGMH 590 TIAAQLLGSG 600 ACINDTMSDG 610 QTLLHMAMQR 620 QDSKSALFLL 630 EHQADINIRT 640 QDGETALQLA 650 IRNQLPLVVD 660 AICTRGADMS 670 VPDEKGNPPL 680 WLALANNLED 690 IASTLVRHGC 700 DATCWGPGPS 710 GCLQTLLHRA 720 IDENNEAIAC 730 FLIRSGCDVN 740 SPRQPGANGE 750 GEEEARDGQT 760 PLHLAASWGL 770 EETIQCLLEF 780 GANVNAQDAE 790 GRTPVHVAIS 800 NQHGVIIQLL 810 ISHPDIHLNV 820 RDRQGLTPFA 830 CAMTYKNNKA 840 AEAILKRESG 850 AAEQVDNKGR 860 NFLHVAVQSS 870 DIESVLFLIS 880 VQANVNSRVQ 890 DASKLTPLHL 900 AVQAGSEIIV 910 RNLLLAGAKV 920 NELTKHRQTA 930 LHLAAQQDLP 940 TICSVLLENG 950 VDFAAVDENG 960 NNALHLAVMH 970 GRLSNIRVLL 980 TECTVDAEAF 990 NLRGQSPLHI 1000 LGQYGKENAA 1010 AVFELFLECM 1020 PEYPLDKPDA 1030 DGNTVLLLAY 1040 MKGNANLCRA 1050 IVRSGARLGV 1060 TNNQGVNIFN 1070 YQVATKQLLF 1080 RLLDMLSKEP 1090 PWCDGSNCYE 1100 CTAKFGVTTR 1110 KHHCRHCGRL 1120 LCHKCSTKEI 1130 PIIKFDLNKP 1140 VRVCNICFDV LTLGGVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010008 endosome membrane
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006897 endocytosis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.