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Overview

Uniprot IDA0A8D1BFA5
Protein NameEukaryotic translation initiation factor 3 subunit L
Gene NameEIF3L
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
159 YRCKTAKKSEEEIDF
253 LENIELNKKSMYSRV
446 RIQLLVFKHKMKNLV
501 FFIRQIHKFEELNRT

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression

Protein Sequence

10 MSYPADDYES 20 ETAYDPYAYP 30 GDYDMHTGDP 40 KQDLAYERQY 50 EQQTYQVIPE 60 VIKNFIQYFH 70 KTVSDLIDQK 80 VYELQASRVS 90 SDVIDQKVYE 100 IQDIYENSWT 110 KLTERFFKNT 120 PWPEAETIAP 130 QVGNDAVFLI 140 LYKELYYRHI 150 YAKVSFQSFS 160 QYRCKTAKKS 170 EEEIDFLRSN 180 PKIWNVHSVL 190 NVLHSLVDKS 200 NINRQLEVYT 210 SGGDPESVAG 220 EYGRHSLYKM 230 LGYFSLVGLL 240 RLHSLLGDYY 250 QAIKVLENIE 260 LNKKSMYSRV 270 PECQVTTYYY 280 VGFAYLMMRR 290 YQDAIRVFAN 300 ILLYIQRTKS 310 MFQRTTYKYE 320 MINKQNEQMH 330 ALLAIALTMY 340 PMRIDESIHL 350 QLREKYGDKM 360 LRMQKGDPQV 370 YEELFSYSCP 380 KFLSPVVPNY 390 DNVHPNYHKE 400 PFLQQLKVFS 410 DEVQQQAQLS 420 TIRSFLKLYT 430 TMPVAKLAGF 440 LDLTEQEFRI 450 QLLVFKHKMK 460 NLVWTSGISA 470 LDGEFQSASE 480 VDFYIDKDMI 490 HIADTKVARR 500 YGDFFIRQIH 510 KFEELNRTLK KMGQRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016282 eukaryotic 43S preinitiation complex
Cellular Component GO:0033290 eukaryotic 48S preinitiation complex
Cellular Component GO:0005852 eukaryotic translation initiation factor 3 complex
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0001732 formation of cytoplasmic translation initiation complex

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.