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Overview

Uniprot IDA0A8D1D3Z6
Protein NameExportin-T
Gene NameXPOT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
683 TPLMEKFKILLEKLM

Function

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Protein Sequence

10 MLSTGCNILD 20 KHILFYQVVF 30 YFNFLYVCAD 40 VCGFFCGIRG 50 HAYCNQKTPS 60 IAARMDEQAL 70 LGLNPNADSD 80 FRQRALAYFE 90 QLKISPDAWQ 100 VCAEALAQRT 110 YSDDHIKFFC 120 FQVLEHQVKY 130 KYSELTTIQQ 140 QLIRETLISW 150 LQAQMLNPQA 160 EKTFIRNKAA 170 QVFALLFVTE 180 YLTKWPKFFF 190 DILSVVDLNP 200 RGVDLYLRIL 210 MAIDSELVDR 220 DVVHTSEEAR 230 RNTLIKDTMR 240 EQCIPNLVES 250 WYQILQNYQY 260 TNSEVTCQCL 270 EVVGAYVSWI 280 DLSLIANDRF 290 INMLLGHMSI 300 EVLREEACDC 310 LFEIVNKGMD 320 PVDKMKLVES 330 LCQVLQSAGF 340 FSIDQEEDVD 350 FLARFSKLVN 360 GMGQSLIVSW 370 TKLIKNGDIK 380 NAQEALQAIE 390 TKVALMLQLL 400 IHEDDDISSN 410 IIGFCYDYLH 420 ILKQLTVLSD 430 QQKANVEAIM 440 LAVMKKLTYD 450 EEYNFENEGE 460 DEAMFVEYRK 470 QLKLLLDRLA 480 QVSPELLLAS 490 VRRVFSSTLQ 500 NWQTTRFMEV 510 EVAIRLLYML 520 AEALPVSHGA 530 HFSGDVSKAS 540 ALQDMMRTLV 550 TSGVSSYQHT 560 SVTLEFFETV 570 VRYEKFFTVE 580 PQHIPCVLMA 590 FLDHRGLRHN 600 SAKVRSRTAY 610 LFSRFVKSLN 620 KQMNPFIEDI 630 LNRIQDLLEL 640 TPPENGYQSL 650 LSSDDQLFIY 660 ETAGVLIVNS 670 EYPAERKQAL 680 MRNLLTPLME 690 KFKILLEKLM 700 LAQDEERQAS 710 LADCLNHAVG 720 FASRTSKAFS 730 NKQTVKQCGC 740 SEVYLDCLQT 750 FLPALSCPLQ 760 KDILRSGVRT 770 FLHRMIICLE 780 EEVLPFIPSA 790 SEHMLKDCEA 800 KDLQEFIPLI 810 NQITAKFKIQ 820 VSPFLQQMFM 830 PLLHAIFEVL 840 LRPAEENDQS 850 AALEKQMLRR 860 SYFAFLQTVT 870 GSGMSEVIAN 880 QGAENVERVL 890 ITVIQGAVEY 900 PDPIAQKTCF 910 IILSKLVELW 920 GGKDGPVGFA 930 DFVYKHIVPA 940 CFLAPLKQTF 950 DLADAQTVLA 960 LSECAVTLKT 970 IHLKRGPECV 980 QYLQQEYLPS 990 LQVAPEIIQE 1000 FCQALQQPDA 1010 KVFKNYLKVF FQRAKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0071528 tRNA re-export from nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.