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Overview

Uniprot IDA0A8D1DEM6
Protein NameZinc finger CCCH domain-containing protein 14
Gene NameZC3H14
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
119 VSSTRPEKRDSRVST
300 SSVVKVKKFNHDGEE
345 PPSKQANKNLILKAI
682 RYFPACKKMECPFYH
720 VPPRHALKWIRPQTR

Function

RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells

Protein Sequence

10 AICFLEASLK 20 LMSIVKMMKD 30 EELPDYIMVM 40 VANKKSQDQM 50 TEDLSLFLGN 60 NTIRFTVWLH 70 GVLDKLRSVT 80 TDPSSFKSSD 90 TNIFDSNVPS 100 NKSSFSRGDE 110 RRHEAAVPPL 120 AVSSTRPEKR 130 DSRVSTSSQE 140 QKATNVRQTY 150 DDGAATRLMS 160 TVKPLREPAP 170 SEDVIDIKPE 180 PDDLIDEDLN 190 FVQENPLSQK 200 KPTVTLTYGS 210 SRPSIEIYRP 220 PASRNADSGA 230 HLNRLQFQQQ 240 QNSIHAAKQV 250 DIQSSRVYET 260 GRLCEPEVLN 270 SLEETYSPFF 280 RNNSEKMSIE 290 EENFRKRKLP 300 VVSSVVKVKK 310 FNHDGEEEEE 320 EDDCGSRTGS 330 ISSSVSVPAK 340 PERRPSLPPS 350 KQANKNLILK 360 AISEAQESVT 370 KTTNYSTVSQ 380 KQTLPVAPRT 390 RTSQEELLAE 400 MVQGQSKAPR 410 ISSPIKEEET 420 KGDNIDKSQG 430 TQQRQLLSRL 440 QIDPVMAETL 450 QISQDYYDME 460 SMVHADTRSF 470 ILKKPKLSEE 480 IVVAPNQESG 490 MKTADTLRVL 500 SGHLMQTRDL 510 VQPDKPASPK 520 FIVTLDGVPS 530 PPGYMSDQEE 540 DMCFEGMRPA 550 HHTAASHEGL 560 AGLLHPQQLH 570 LLSRQLEDPD 580 GSFSNAEMSE 590 LSVAQKPEKL 600 LERCKYWPAC 610 KNGDECAYHH 620 PISPCKAFPN 630 CKFAEKCLFV 640 HPNCKYDAKC 650 TKPDCPFTHM 660 SRRIPVLPPK 670 PVTTPAPPSS 680 SQLCRYFPAC 690 KKMECPFYHP 700 KHCRFNTQCT 710 RPDCTFYHPT 720 ITVPPRHALK WIRPQTR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Molecular Function GO:0008143 poly(A) binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0043488 regulation of mRNA stability

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.