Search Results
Overview
| Uniprot ID | A0A8D1DH38 |
|---|---|
| Protein Name | Replication protein A subunit |
| Gene Name | RPA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | SKAYGASKIFGKAGA |
| 136 | GASKIFGKAGATSVV |
| 175 | ICARVTNKSQIRTWS |
| 228 | NKVYYFSKGTLKIAN |
| 232 | YFSKGTLKIANKQFT |
| 236 | GTLKIANKQFTAVKN |
| 300 | KNYEDVTKITVKSTN |
| 304 | DVTKITVKSTNREVS |
| 458 | PTQDCNKKVIDQQNG |
| 546 | FTFRIRVKLETYNDE |
| 88 | RFIVNTLKDGRRVVI |
Function
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage
Protein Sequence
10
MVGHLSEGAI
20
AAIMQQGDTS
30
IKPILQVINI
40
RPITTGNNPP
50
RYRLLMSDGL
60
NTLSSFMLAT
70
QLNPLVEEER
80
LSSNCICQIN
90
RFIVNTLKDG
100
RRVVILMDLE
110
VLKSAEAVGV
120
KIGNPVPYNE
130
GSTVSKAYGA
140
SKIFGKAGAT
150
SVVNSSGGTQ
160
AKVVPIASLT
170
PYQSKWTICA
180
RVTNKSQIRT
190
WSNSRGEGKL
200
FSIELVDESG
210
EIRATAFNEQ
220
VDKFFPLIDV
230
NKVYYFSKGT
240
LKIANKQFTA
250
VKNDYEMTFS
260
NETSVMPCED
270
GHHLPTVQFD
280
FTGIADLENK
290
SKDSLVDIIG
300
ICKNYEDVTK
310
ITVKSTNREV
320
SKRNIYLMDM
330
SGKVVNATLW
340
GEDADKFDGS
350
RQPVMAIKGA
360
RVSDFGGRSL
370
SILSSSTVIV
380
NPDIPEAYKL
390
RGWFDSEGQA
400
LDGVSISDLK
410
SGGIGGSNTN
420
WKTLYEVKSE
430
NLGQGDKPDY
440
FSAVATVVYL
450
RKENCMYQAC
460
PTQDCNKKVI
470
DQQNGLYRCE
480
KCDSEFPNFK
490
YRMILSVNIA
500
DFQENQWVTC
510
FQESAEAILG
520
QSTAYLGELK
530
EKNEQAFEEV
540
FQNANFRSFT
550
FRIRVKLETY
560
NDESRIKGTV
570
MDVKPVDYKE
580
YGRRLIMSIR
KNAAM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000228 | nuclear chromosome |
| Cellular Component | GO:0016605 | PML body |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006260 | DNA replication |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.