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Overview

Uniprot IDA0A8D1GCI9
Protein NameEndoplasmic reticulum disulfide reductase DNAJC10
Gene NameDNAJC10
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
748 IRAYPTVKFYPYEGT

Function

Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress

Protein Sequence

10 MGVWLNKDAY 20 IRDLKRVILC 30 FLLVYMAILV 40 GTDQDFYSLL 50 GVSKTASSRE 60 IRQAFKKLAL 70 KLHPDKNPNN 80 PNAHSDFLKI 90 NKAYEVLKDE 100 DLRKKYDKYG 110 EKGLADNQGG 120 GQYESWNYYR 130 YDFGIYDDDP 140 EIITLDRSEF 150 DAAVNSGELW 160 FVNFYSSGCS 170 HCHDLAPTWR 180 DFAREVDGLL 190 RIGAVNCGDD 200 RMLCRMKGVS 210 SYPSLFIFRS 220 GMAAVKYHGD 230 RSKESLVNFA 240 MQYVRSTVTE 250 LWTGNFVNSI 260 QTAFAAGIGW 270 LITFCSKGGD 280 CLTSQTRLRL 290 SGMLDGLVNV 300 GWMDCATQDN 310 LCKSLDITTS 320 TTAYFPPGAT 330 LNNKEKSSIL 340 FLNSLDAKEI 350 YLEIMHNLPD 360 FELLSANTLE 370 DRLAHHRWLL 380 FFYFGKNEFS 390 NDPELKKLKT 400 LLKNEHIQVG 410 KFDCSSAPDI 420 CSNLYVFQPC 430 LAVFKGQGTK 440 EFEIHHGKKI 450 LYDILAFAKE 460 SVNSHVTTLG 470 PQNFPTSDKE 480 PWLVDFFAPW 490 CPPCRALLPE 500 LRKASKHLYG 510 QLKFGTLDCT 520 VHEGLCNMYN 530 IQAYPTTVVF 540 NQSNIHEYEG 550 HHSAEQILEF 560 VEDLMNPSVV 570 SLTPTTFDEL 580 VRQRKPDEVW 590 MVDFYSPWCH 600 PCQVLMPEWK 610 RMARTLTGLI 620 NVGSIDCQQY 630 HSLCAQENVR 640 RYPEIRFFPQ 650 KSNKAYQYHS 660 YNGWNRDAYS 670 LRIWGLGFLP 680 QASIDLTPQT 690 FNEKVLQGKS 700 HWVVDFYAPW 710 CGPCQNFAPE 720 FELLARMVKE 730 KVKAGKVDCQ 740 AYAQTCQKAG 750 IRAYPTVKFY 760 PYEGTRRNIW 770 GEQIDSRDAK 780 EITTLIYEKL 790 ENLQNHGKRN 800 KVRNLEFTLT NII

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034663 endoplasmic reticulum chaperone complex
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0030544 Hsp70 protein binding
Molecular Function GO:0051787 misfolded protein binding
Molecular Function GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Molecular Function GO:0015035 protein-disulfide reductase activity
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0034975 protein folding in endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Molecular Function GO:0001671 ATPase activator activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.